6W7F

Structure of EED bound to inhibitor 5285

Summary for 6W7F

• Entry DOI: 10.2210/pdb6w7f/pdb
• Descriptor: Polycomb protein EED, 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, GLYCEROL, ... (4 entities in total)
• Functional Keywords: inhibitor, gene regulation, transcription-inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 43463.33

Authors

Petrunak, E.M.,Stuckey, J.A. (deposition date: 2020-03-19, release date: 2020-07-08, Last modification date: 2023-10-18)

• Primary citation: Rej, R.K.,Wang, C.,Lu, J.,Wang, M.,Petrunak, E.,Zawacki, K.P.,McEachern, D.,Fernandez-Salas, E.,Yang, C.Y.,Wang, L.,Li, R.,Chinnaswamy, K.,Wen, B.,Sun, D.,Stuckey, J.,Zhou, Y.,Chen, J.,Tang, G.,Wang, S.; EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.; J.Med.Chem., 63:7252-7267, 2020; PubMed: 32580550; DOI: 10.1021/acs.jmedchem.0c00479

Experimental method

X-RAY DIFFRACTION (2.2 Å)