6W7F

Structure of EED bound to inhibitor 5285

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016571	biological_process	histone methylation
A	0035098	cellular_component	ESC/E(Z) complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue Q3D A 501

Chain	Residue
A	PHE97
A	ARG414
A	HOH731
A	HOH756
A	TYR148
A	ASN194
A	LYS211
A	LEU240
A	ASP310
A	TYR365
A	MET366
A	ARG367

---

site_id	AC2
Number of Residues	12
Details	binding site for residue Q3D A 502

Chain	Residue
A	HIS199
A	ARG201
A	ASP202
A	LEU205
A	LEU247
A	GLY248
A	ILE265
A	MET271
A	ILE274
A	LYS275
A	TYR278
A	HOH735

---

site_id	AC3
Number of Residues	9
Details	binding site for residue GOL A 503

Chain	Residue
A	GLY188
A	HIS189
A	GLY190
A	ASN191
A	ILE193
A	SER208
A	SER210
A	ASP212
A	ARG216

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI

Chain	Residue	Details
A	LEU206-ILE220

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	43
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	43
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	40
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	41
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	37
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	154
Details	Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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