2JY6
 
 | |
2KHW
 | | Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex | | Descriptor: | Immunoglobulin G-binding protein G, DNA polymerase iota, Ubiquitin | | Authors: | Bomar, M.G, D'Souza, S, Bienko, M, Dikic, I, Walker, G. | | Deposit date: | 2009-04-13 | | Release date: | 2010-02-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex
To be Published
|
|
2KWV
 | | Solution Structure of UBM1 of murine Polymerase iota in Complex with Ubiquitin | | Descriptor: | DNA polymerase iota, Ubiquitin | | Authors: | Burschowsky, D, Rudolf, F, Rabut, G, Herrmann, T, Peter, M, Wider, G. | | Deposit date: | 2010-04-20 | | Release date: | 2010-10-06 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin.
J.Biol.Chem., 286, 2011
|
|
2KWU
 | | Solution Structure of UBM2 of murine Polymerase iota in Complex with Ubiquitin | | Descriptor: | DNA polymerase iota, Ubiquitin | | Authors: | Burschowsky, D, Rudolf, F, Rabut, G, Herrmann, T, Peter, M, Wider, G. | | Deposit date: | 2010-04-19 | | Release date: | 2010-10-06 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin.
J.Biol.Chem., 286, 2011
|
|
9BJU
 | | Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5 | | Descriptor: | 1,2-ETHANEDIOL, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ACETATE ION, ... | | Authors: | Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A. | | Deposit date: | 2024-04-25 | | Release date: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability
To Be Published
|
|
9AZJ
 | |
9EQJ
 | | Crystal structure of pVHL:EloB:EloC in complex with MP-1-39 | | Descriptor: | (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[cis-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | Authors: | Kroupova, A, Pierri, M, Liu, X, Ciulli, A. | | Deposit date: | 2024-03-21 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.
Bioorg.Med.Chem.Lett., 110, 2024
|
|
9EQM
 | | Crystal structure of pVHL:EloB:EloC in complex with MP-1-21 | | Descriptor: | (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[trans-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | Authors: | Kroupova, A, Pierri, M, Liu, X, Ciulli, A. | | Deposit date: | 2024-03-21 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.
Bioorg.Med.Chem.Lett., 110, 2024
|
|
9B0Z
 | |
9B12
 | |
9FCJ
 | | USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement) | | Descriptor: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ... | | Authors: | Rennie, M.L, Gundogdu, M, Walden, H. | | Deposit date: | 2024-05-15 | | Release date: | 2024-09-04 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 67, 2024
|
|
9FCI
 | | USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement) | | Descriptor: | 6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ... | | Authors: | Rennie, M.L, Gundogdu, M, Walden, H. | | Deposit date: | 2024-05-15 | | Release date: | 2024-09-04 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 67, 2024
|
|
9C5E
 | | Covalent Complex Between Parkin Catalytic (Rcat) Domain and Ubiquitin | | Descriptor: | E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ZINC ION | | Authors: | Connelly, E.M, Rintala-Dempsey, A.C, Gundogdu, M, Freeman, E.A, Koszela, J, Aguirre, J.D, Zhu, G, Kamarainen, O, Tadayon, R, Walden, H, Shaw, G.S. | | Deposit date: | 2024-06-06 | | Release date: | 2024-08-14 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | Capturing the catalytic intermediates of parkin ubiquitination.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
2L0T
 | | Solution structure of the complex of ubiquitin and the VHS domain of Stam2 | | Descriptor: | Signal transducing adapter molecule 2, Ubiquitin | | Authors: | Lange, A, Hoeller, D, Wienk, H, Marcillat, O, Lancelin, J, Walker, O. | | Deposit date: | 2010-07-15 | | Release date: | 2010-12-15 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | NMR reveals a different mode of binding of the Stam2 VHS domain to ubiquitin and diubiquitin.
Biochemistry, 50, 2011
|
|
2LVO
 | | Structure of the gp78CUE domain bound to monubiquitin | | Descriptor: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | | Authors: | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | | Deposit date: | 2012-07-09 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains.
Structure, 20, 2012
|
|
2LVP
 | | gp78CUE domain bound to the distal ubiquitin of K48-linked diubiquitin | | Descriptor: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | | Authors: | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | | Deposit date: | 2012-07-09 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains.
Structure, 20, 2012
|
|
2MBB
 | | Solution Structure of the human Polymerase iota UBM1-Ubiquitin Complex | | Descriptor: | Immunoglobulin G-binding protein G/DNA polymerase iota fusion protein, Polyubiquitin-B | | Authors: | Wang, S, Zhou, P. | | Deposit date: | 2013-07-29 | | Release date: | 2014-06-04 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes.
J.Biomol.Nmr, 59, 2014
|
|
2MBH
 | | NMR structure of EKLF(22-40)/Ubiquitin Complex | | Descriptor: | Krueppel-like factor 1, Ubiquitin | | Authors: | Raiola, L, Omichinski, J.G. | | Deposit date: | 2013-07-31 | | Release date: | 2013-10-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Characterization of a Noncovalent Complex between Ubiquitin and the Transactivation Domain of the Erythroid-Specific Factor EKLF.
Structure, 21, 2013
|
|
2LVQ
 | | gp78CUE domain bound to the proximal ubiquitin of K48-linked diubiquitin | | Descriptor: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | | Authors: | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | | Deposit date: | 2012-07-09 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains.
Structure, 20, 2012
|
|
2MCN
 | | Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications | | Descriptor: | CD2-associated protein, Ubiquitin | | Authors: | Ortega-Roldan, J, Salmon, L, Azuaga, A, Blackledge, M, Van Nuland, N. | | Deposit date: | 2013-08-22 | | Release date: | 2014-02-05 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications.
Plos One, 8, 2013
|
|
2N3W
 | |
2NBW
 | | Solution structure of the Rpn1 T1 site with the Rad23 UBL domain | | Descriptor: | 26S proteasome regulatory subunit RPN1, UV excision repair protein RAD23 | | Authors: | Chen, X, Walters, K.J. | | Deposit date: | 2016-03-14 | | Release date: | 2016-07-20 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.
Structure, 24, 2016
|
|
2NBV
 | |
2N3V
 | |
2MRO
 | |
