9EQJ

Crystal structure of pVHL:EloB:EloC in complex with MP-1-39

This is a non-PDB format compatible entry.

Summary for 9EQJ

• Entry DOI: 10.2210/pdb9eqj/pdb
• Related: 9EQM
• Descriptor: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
• Functional Keywords: e3 ligase, von hippel-lindau tumor-suppressor protein, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 84310.56

Authors

Kroupova, A.,Pierri, M.,Liu, X.,Ciulli, A. (deposition date: 2024-03-21, release date: 2024-08-28)

• Primary citation: Pierri, M.,Liu, X.,Kroupova, A.,Rutter, Z.,Hallatt, A.J.,Ciulli, A.; Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.; Bioorg.Med.Chem.Lett., 110:129861-129861, 2024; PubMed: 38942127; DOI: 10.1016/j.bmcl.2024.129861

Experimental method

X-RAY DIFFRACTION (2.05 Å)