4DDI
 
 | | Crystal structure of human OTUB1/UbcH5b~Ub/Ub | | Descriptor: | Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1 | | Authors: | Juang, Y.C, Sanches, M, Sicheri, F. | | Deposit date: | 2012-01-18 | | Release date: | 2012-02-22 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (3.802 Å) | | Cite: | OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function.
Mol.Cell, 45, 2012
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5A31
 | | Structure of the human APC-Cdh1-Hsl1-UbcH10 complex. | | Descriptor: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... | | Authors: | Chang, L, Zhang, Z, Yang, J, Mclaughlin, S.H, Barford, D. | | Deposit date: | 2015-05-26 | | Release date: | 2015-11-18 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Atomic Structure of the Apc/C and its Mechanism of Protein Ubiquitination.
Nature, 522, 2015
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4BWF
 | | Pex4p-Pex22p disulphide bond mutant | | Descriptor: | 1,2-ETHANEDIOL, PEROXISOME ASSEMBLY PROTEIN 22, UBIQUITIN-CONJUGATING ENZYME E2-21 KDA | | Authors: | Williams, C, van den Berg, M, Stanley, W.A, Wilmanns, M, Distel, B. | | Deposit date: | 2013-07-01 | | Release date: | 2013-07-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.23 Å) | | Cite: | A Disulphide Bond in the E2 Enzyme Pex4P Modulates Ubiquitin-Conjugating Activity
Sci.Rep., 3, 2013
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4ORH
 | | Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer | | Descriptor: | E3 ubiquitin-protein ligase RNF8, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2, ... | | Authors: | Campbell, S.J, Edwards, R.A, Glover, J.N.M. | | Deposit date: | 2014-02-11 | | Release date: | 2014-02-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (4.802 Å) | | Cite: | Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
J.Biol.Chem., 287, 2012
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4DHZ
 | | The structure of h/ceOTUB1-ubiquitin aldehyde-UBC13~Ub | | Descriptor: | Ubiquitin, Ubiquitin aldehyde, Ubiquitin thioesterase otubain-like, ... | | Authors: | Wiener, R, Zhang, X, Wang, T, Wolberger, C. | | Deposit date: | 2012-01-30 | | Release date: | 2012-02-22 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (3.11 Å) | | Cite: | The mechanism of OTUB1-mediated inhibition of ubiquitination.
Nature, 483, 2012
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5BNB
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4TKP
 | | Complex of Ubc13 with the RING domain of the TRIM5alpha retroviral restriction factor | | Descriptor: | SULFATE ION, Tripartite motif-containing protein 5, Ubiquitin-conjugating enzyme E2 N, ... | | Authors: | Johnson, R, Taylor, A.B, Hart, P.J, Ivanov, D.N. | | Deposit date: | 2014-05-27 | | Release date: | 2015-07-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | RING Dimerization Links Higher-Order Assembly of TRIM5 alpha to Synthesis of K63-Linked Polyubiquitin.
Cell Rep, 12, 2015
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4DDG
 | | Crystal structure of human OTUB1/UbcH5b~Ub/Ub | | Descriptor: | Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1 | | Authors: | Juang, Y.C, Sanches, M, Sicheri, F. | | Deposit date: | 2012-01-18 | | Release date: | 2012-02-22 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.2987 Å) | | Cite: | OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function.
Mol.Cell, 45, 2012
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4S3O
 | | PCGF5-RING1B-UbcH5c complex | | Descriptor: | E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ... | | Authors: | Taherbhoy, A.M, Cochran, A.G. | | Deposit date: | 2015-03-23 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Nat Commun, 6, 2015
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5D1L
 | | Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (Y165A) | | Descriptor: | DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, OXALATE ION, ... | | Authors: | Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. | | Deposit date: | 2015-08-04 | | Release date: | 2015-10-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.618 Å) | | Cite: | Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
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5D1K
 | | Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ... | | Authors: | Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. | | Deposit date: | 2015-08-04 | | Release date: | 2015-10-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
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5D0K
 | | Structure of UbE2D2:RNF165:Ub complex | | Descriptor: | Polyubiquitin-B, RING finger protein 165, Ubiquitin-conjugating enzyme E2 D2, ... | | Authors: | Wright, J.D, Day, C.L, Mace, P.D. | | Deposit date: | 2015-08-03 | | Release date: | 2015-12-09 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.
Nat.Struct.Mol.Biol., 23, 2016
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5D0M
 | | Structure of UbE2D2:RNF165:Ub complex | | Descriptor: | PHOSPHATE ION, Polyubiquitin-B, RING finger protein 165, ... | | Authors: | Wright, J.D, Day, C.L, Mace, P.D. | | Deposit date: | 2015-08-03 | | Release date: | 2015-12-09 | | Last modified: | 2016-01-20 | | Method: | X-RAY DIFFRACTION (1.913 Å) | | Cite: | Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.
Nat.Struct.Mol.Biol., 23, 2016
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4CCG
 | | Structure of an E2-E3 complex | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMMONIUM ION, CHLORIDE ION, ... | | Authors: | Hodson, C, Purkiss, A, Walden, H. | | Deposit date: | 2013-10-22 | | Release date: | 2014-01-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of the Human Fancl Ring-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection.
Structure, 22, 2014
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7ZJ3
 | | Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate | | Descriptor: | Polyubiquitin-C, Tripartite motif-containing protein 2, Ubiquitin-conjugating enzyme E2 D1, ... | | Authors: | Esposito, D, Garza-Garcia, A, Dudley-Fraser, J, Rittinger, K. | | Deposit date: | 2022-04-08 | | Release date: | 2022-11-30 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
Nat Commun, 13, 2022
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2GRR
 | | Crystal Structure of human RanGAP1-Ubc9-D127S | | Descriptor: | Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I | | Authors: | Yunus, A.A, Lima, C.D. | | Deposit date: | 2006-04-24 | | Release date: | 2006-05-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
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8ATX
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8ATU
 | | Cryo-EM structure of human BIRC6 | | Descriptor: | Baculoviral IAP repeat-containing protein 6, ZINC ION | | Authors: | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | | Deposit date: | 2022-08-24 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Science, 379, 2023
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8AUW
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8AUK
 | | Cryo-EM structure of human BIRC6 in complex with HTRA2. | | Descriptor: | Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial, ... | | Authors: | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | | Deposit date: | 2022-08-25 | | Release date: | 2023-02-15 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Science, 379, 2023
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2KJH
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8ATM
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8ATO
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8B3I
 | | CRL4CSA-E2-Ub (state 2) | | Descriptor: | Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ... | | Authors: | Kokic, G, Cramer, P. | | Deposit date: | 2022-09-16 | | Release date: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | C(N)RL4CSA-E2-Ub (state 2)
To Be Published
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8AMS
 | | Complex of human TRIM2 RING domain, UBCH5C, and Ubiquitin | | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Polyubiquitin-C, ... | | Authors: | Perez-Borrajero, C, Kotova, I, Murciano, B, Hennig, J. | | Deposit date: | 2022-08-04 | | Release date: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and biophysical studies of TRIM2 and TRIM3
To Be Published
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