5M3N
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![BU of 5m3n by Molmil](/molmil-images/mine/5m3n) | HTRA2 wild-type structure | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Serine protease HTRA2, mitochondrial | Authors: | Merski, M, Pereira, P.J.B, Macedo-Ribeiro, S. | Deposit date: | 2016-10-15 | Release date: | 2017-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.649 Å) | Cite: | Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2. Cell Death Dis, 8, 2017
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5TO1
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![BU of 5to1 by Molmil](/molmil-images/mine/5to1) | HtrA2 exposed (L266R, F303A) mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Serine protease HTRA2, ... | Authors: | Merski, M, Barbosa Pereira, P.J, Macedo-Ribeiro, S. | Deposit date: | 2016-10-15 | Release date: | 2017-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2. Cell Death Dis, 8, 2017
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5M3O
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![BU of 5m3o by Molmil](/molmil-images/mine/5m3o) | HTRA2 A141S mutant structure | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Serine protease HTRA2, mitochondrial | Authors: | Merski, M, Barbosa Pereira, P.J, Macedo-Ribeiro, S. | Deposit date: | 2016-10-15 | Release date: | 2017-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2. Cell Death Dis, 8, 2017
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5TNY
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![BU of 5tny by Molmil](/molmil-images/mine/5tny) | HTRA2 G399S mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Serine protease HTRA2, mitochondrial | Authors: | Merski, M, Barbosa Pereira, P.J, Macedo-Ribeiro, S. | Deposit date: | 2016-10-15 | Release date: | 2017-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2. Cell Death Dis, 8, 2017
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5TNZ
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![BU of 5tnz by Molmil](/molmil-images/mine/5tnz) | HtrA2 S142D mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, Serine protease HTRA2, ... | Authors: | Macedo-Ribeiro, S, Merski, M, Pereira, P.J.B. | Deposit date: | 2016-10-15 | Release date: | 2017-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2. Cell Death Dis, 8, 2017
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5TO0
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![BU of 5to0 by Molmil](/molmil-images/mine/5to0) | HTRA2 S276C mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Serine protease HTRA2, mitochondrial | Authors: | Merski, M, Barbosa Pereira, P.J, Macedo-Ribeiro, S. | Deposit date: | 2016-10-15 | Release date: | 2017-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2. Cell Death Dis, 8, 2017
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5FHT
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![BU of 5fht by Molmil](/molmil-images/mine/5fht) | HtrA2 protease mutant V226K | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, POTASSIUM ION, ... | Authors: | Golik, P, Dubin, G, Zurawa-Janicka, D, Lipinska, B, Jarzab, M, Wenta, T, Gieldon, A, Ciarkowski, A. | Deposit date: | 2015-12-22 | Release date: | 2016-09-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants. Plos One, 11, 2016
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1LCY
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![BU of 1lcy by Molmil](/molmil-images/mine/1lcy) | Crystal Structure of the Mitochondrial Serine Protease HtrA2 | Descriptor: | HtrA2 serine protease | Authors: | Li, W, Srinivasula, S.M, Chai, J, Li, P, Wu, J.W, Zhang, Z, Alnemri, E.S, Shi, Y. | Deposit date: | 2002-04-07 | Release date: | 2002-05-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nat.Struct.Biol., 9, 2002
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5WYN
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![BU of 5wyn by Molmil](/molmil-images/mine/5wyn) | HtrA2 Pathogenic Mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Serine protease HTRA2, ... | Authors: | Wagh, A.R, Bose, K. | Deposit date: | 2017-01-13 | Release date: | 2018-08-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2 Biosci. Rep., 38, 2018
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2PZD
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![BU of 2pzd by Molmil](/molmil-images/mine/2pzd) | |
8E2K
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![BU of 8e2k by Molmil](/molmil-images/mine/8e2k) | Cryo-EM structure of BIRC6/HtrA2-S306A | Descriptor: | Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2022-08-15 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science, 379, 2023
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7VGE
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![BU of 7vge by Molmil](/molmil-images/mine/7vge) | Structure of the PDZ deleted variant of HtrA2 protease (S306A) | Descriptor: | Serine protease HTRA2, mitochondrial | Authors: | Parui, A.L, Mishra, V, Bhaumik, P, Bose, K. | Deposit date: | 2021-09-15 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2. Structure, 30, 2022
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8AUK
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![BU of 8auk by Molmil](/molmil-images/mine/8auk) | Cryo-EM structure of human BIRC6 in complex with HTRA2. | Descriptor: | Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial, ... | Authors: | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | Deposit date: | 2022-08-25 | Release date: | 2023-02-15 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
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