5TO1
HtrA2 exposed (L266R, F303A) mutant
Summary for 5TO1
| Entry DOI | 10.2210/pdb5to1/pdb |
| Related | 5m3n 5m3o 5tny 5tnz 5to0 |
| Descriptor | Serine protease HTRA2, mitochondrial, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | serine protease, parkinson disease, mitochondria, pdz dynamics, hydrolase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Mitochondrion intermembrane space: O43464 |
| Total number of polymer chains | 1 |
| Total formula weight | 36454.24 |
| Authors | Merski, M.,Barbosa Pereira, P.J.,Macedo-Ribeiro, S. (deposition date: 2016-10-15, release date: 2017-10-25, Last modification date: 2024-01-17) |
| Primary citation | Merski, M.,Moreira, C.,Abreu, R.M.,Ramos, M.J.,Fernandes, P.A.,Martins, L.M.,Pereira, P.J.B.,Macedo-Ribeiro, S. Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2. Cell Death Dis, 8:e3119-e3119, 2017 Cited by PubMed: 29022916DOI: 10.1038/cddis.2017.487 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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