5TO1
HtrA2 exposed (L266R, F303A) mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine protease HTRA2, mitochondrial | polymer | 334 | 36188.1 | 1 | UniProt (O43464) Pfam (PF13365) Pfam (PF17820) | Homo sapiens (Human) | High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI |
| 2 | B (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E (A) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A: 134 - 458 (UniProt: O43464)
| PDB | External Database | Details |
|---|---|---|
| Met 133 | - | initiating methionine |
| Arg 266 | Leu 266 | engineered mutation |
| Ala 303 | Phe 303 | engineered mutation |
| Leu 459 | - | expression tag |
| Glu 460 | - | expression tag |
| His 461 | - | expression tag |
| His 462 | - | expression tag |
| His 463 | - | expression tag |
| His 464 | - | expression tag |
| His 465 | - | expression tag |
| His 466 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36188.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 266.1 | |
| All* | Total formula weight | 36454.2 |
