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5TO1

HtrA2 exposed (L266R, F303A) mutant

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ASerine protease HTRA2, mitochondrialpolymer33436188.11UniProt (O43464)
Pfam (PF13365)
Pfam (PF17820)
In PDB
Homo sapiens (Human)High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI
2A2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.21Chemie (MES)
3ACHLORIDE IONnon-polymer35.52Chemie (CL)
4waterwater18.0164Chemie (HOH)
Sequence modifications
A: 134 - 458 (UniProt: O43464)
PDBExternal DatabaseDetails
Met 133-initiating methionine
Arg 266Leu 266engineered mutation
Ala 303Phe 303engineered mutation
Leu 459-expression tag
Glu 460-expression tag
His 461-expression tag
His 462-expression tag
His 463-expression tag
His 464-expression tag
His 465-expression tag
His 466-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight36188.1
Non-Polymers*Number of molecules3
Total formula weight266.1
All*Total formula weight36454.2
*Water molecules are not included.

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PDB entries from 2024-07-10

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