PDB: 1406 件ウェブページステータス検索Chemie searchBIRD

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9EO0	Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 分子名称: Programmed cell death 1 ligand 1, SULFATE ION, ~{N}-[3-[3-[[5-[(2-hydroxyethylamino)methyl]pyridin-2-yl]carbonylamino]-2-methyl-phenyl]-2-methyl-phenyl]-5-[[3-(methylsulfonylamino)propylamino]methyl]pyridine-2-carboxamide 著者 Plewka, J, Hec, A, Sitar, T, Holak, T. 登録日 2024-03-14 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Nonsymmetrically Substituted 1,1'-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction. Acs Med.Chem.Lett., 15, 2024
8YC0	T cell receptor V delta2 V gamma9 in GDN 分子名称: CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... 著者 Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2024-02-17 公開日 2024-05-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.12 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
8RPB	Structure of S79 Fab in complex with IgV domain of human PD-L1 分子名称: CHLORIDE ION, GLYCEROL, Programmed cell death 1 ligand 1, ... 著者 Svensson, A, Kelpsas, V, Laursen, M, Rose, N. 登録日 2024-01-15 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.794 Å) 主引用文献 Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1. Mabs, 16, 2024
8XMN	Voltage-gated sodium channel Nav1.7 variant M2 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Yan, N, Li, Z, Wu, Q, Huang, G. 登録日 2023-12-27 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
8XMO	Voltage-gated sodium channel Nav1.7 variant M4 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Yan, N, Li, Z, Wu, Q, Huang, G. 登録日 2023-12-27 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
8XMM	Voltage-gated sodium channel Nav1.7 variant M9 分子名称: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... 著者 Yan, N, Li, Z, Wu, Q, Huang, G. 登録日 2023-12-27 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
8R6Q	Co-crystal structure of PD-L1 with low molecular weight inhibitor 分子名称: (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, Programmed cell death 1 ligand 1, ... 著者 Plewka, J, Surmiak, E, Magiera-Mularz, K, Kalinowska-Tluscik, J. 登録日 2023-11-22 公開日 2024-01-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives. Acs Med.Chem.Lett., 15, 2024
8X6B	Crystal structure of immune receptor PVRIG in complex with ligand Nectin-2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nectin-2, Transmembrane protein PVRIG 著者 Hu, S.T, Han, P, Wang, H, Qi, J.X. 登録日 2023-11-21 公開日 2024-04-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2. Structure, 2024
8WYI	T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC 分子名称: Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... 著者 Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-10-31 公開日 2024-05-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
8WY0	T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A 分子名称: CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... 著者 Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-10-30 公開日 2024-05-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
8WXE	Vgamma5Vdelta1 EH TCR-CD3 complex 分子名称: CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 1,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 5,T cell receptor gamma constant 1, ... 著者 Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-10-28 公開日 2024-05-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
8WUL	Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) 分子名称: Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen, ... 著者 Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. 登録日 2023-10-20 公開日 2024-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen. Commun Biol, 7, 2024
8WTE	Crystal structure of TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) 分子名称: Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen (Fragment), ... 著者 Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. 登録日 2023-10-18 公開日 2024-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen. Commun Biol, 7, 2024
8U31	Crystal structure of PD-1 in complex with a Fab 分子名称: Fab heavy chain, Fab light chain, GLYCEROL, ... 著者 Sun, D, Masureel, M. 登録日 2023-09-07 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
8U32	Crystal structure of PD-1 in complex with a Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... 著者 Sun, D, Masureel, M. 登録日 2023-09-07 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
8QH1	Crystal structure of the SARS-CoV-2 RBD from the Omicron BA4 variant with the antibody Cv2.3194 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cv2.3194 heavy chain, IGK@ protein, ... 著者 Fernandez, I, Rey, F.A. 登録日 2023-09-06 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Pan-neutralizing antibody isolated from a COVID patient To Be Published
8QH0	Crystal structure of the SARS-CoV-2 RBD with the antibody Cv2.3194 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cv2.3194 Heavy chain, GLYCEROL, ... 著者 Fernandez, I, Rey, F.A. 登録日 2023-09-06 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 A broadly neutralizing antibody against SARS-CoV-2 Omicron variants To Be Published
8TQK	Human parainfluenza virus type 3 prefusion F trimer in complex with rPIV3-18 Fab 分子名称: Fusion glycoprotein F0, Heavy chain Fab rPIV3-18, Light chain Fab rPIV3-28 著者 Otrelo-Cardoso, A.R, Jardetzky, T.S. 登録日 2023-08-07 公開日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Functional and structural characteristics of human monoclonal antibodies that potently neutralize human parainfluenza virus type 3 To be published
8K5N	Discovery of Novel PD-L1 Inhibitors That Induce Dimerization and Degradation of PD-L1 Based on Fragment Coupling Strategy 分子名称: 3-[(1~{S})-1-[6-methoxy-3-methyl-5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyridin-2-yl]oxy-2,3-dihydro-1~{H}-inden-4-yl]-2-methyl-~{N}-[5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyridin-2-yl]benzamide, Programmed cell death 1 ligand 1 著者 Cheng, Y, Xiao, Y.B. 登録日 2023-07-22 公開日 2024-01-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy. J.Med.Chem., 66, 2023
8THH	Cryo-EM structure of Nav1.7 with LTG 分子名称: (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... 著者 Fan, X, Huang, J, Yan, N. 登録日 2023-07-16 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8THG	Cryo-EM structure of Nav1.7 with RLZ 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Fan, X, Huang, J, Yan, N. 登録日 2023-07-16 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8TE6	Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain 分子名称: V-set and immunoglobulin domain-containing protein 4 著者 Abram, T.G, Geisbrecht, B.V. 登録日 2023-07-05 公開日 2023-07-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.251 Å) 主引用文献 New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023
8TE5	Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain 分子名称: V-set and immunoglobulin domain-containing protein 4 著者 Abram, T.G, Geisbrecht, B.V. 登録日 2023-07-05 公開日 2023-07-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.502 Å) 主引用文献 New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023
8TBQ	The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, SNS-101 Fab heavy chain, ... 著者 van der Horst, E.H, Mukherjee, A, Thisted, T. 登録日 2023-06-29 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.593 Å) 主引用文献 The pH-selective anti-VISTA antibody SNS-101 displays a favorable pharmacokinetic and safety profile and promotes anti-tumoral M1 macrophage polarization in PD-1 refractory settings To Be Published
8SZY	Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BMS-986207 Fab Heavy Chain, BMS-986207 light chain, ... 著者 Diong, S.J, Lee, P.S. 登録日 2023-05-30 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT. Mabs, 15, 2023

 

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