PDB: 1399 件ウェブページステータス検索Chemie searchBIRD

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8YC0	T cell receptor V delta2 V gamma9 in GDN 分子名称: CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... 著者 Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2024-02-17 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (4.12 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 2024
8XMM	Voltage-gated sodium channel Nav1.7 variant M9 分子名称: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... 著者 Yan, N, Li, Z, Wu, Q, Huang, G. 登録日 2023-12-27 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
8XMN	Voltage-gated sodium channel Nav1.7 variant M2 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Yan, N, Li, Z, Wu, Q, Huang, G. 登録日 2023-12-27 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
8XMO	Voltage-gated sodium channel Nav1.7 variant M4 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Yan, N, Li, Z, Wu, Q, Huang, G. 登録日 2023-12-27 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
8R6Q	Co-crystal structure of PD-L1 with low molecular weight inhibitor 分子名称: (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, Programmed cell death 1 ligand 1, ... 著者 Plewka, J, Surmiak, E, Magiera-Mularz, K, Kalinowska-Tluscik, J. 登録日 2023-11-22 公開日 2024-01-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives. Acs Med.Chem.Lett., 15, 2024
8X6B	Crystal structure of immune receptor PVRIG in complex with ligand Nectin-2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nectin-2, Transmembrane protein PVRIG 著者 Hu, S.T, Han, P, Wang, H, Qi, J.X. 登録日 2023-11-21 公開日 2024-04-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2. Structure, 2024
8WYI	T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC 分子名称: Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... 著者 Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-10-31 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 2024
8WY0	T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A 分子名称: CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... 著者 Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-10-30 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 2024
8WXE	Vgamma5Vdelta1 EH TCR-CD3 complex 分子名称: CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 1,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 5,T cell receptor gamma constant 1, ... 著者 Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-10-28 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 2024
8K5N	Discovery of Novel PD-L1 Inhibitors That Induce Dimerization and Degradation of PD-L1 Based on Fragment Coupling Strategy 分子名称: 3-[(1~{S})-1-[6-methoxy-3-methyl-5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyridin-2-yl]oxy-2,3-dihydro-1~{H}-inden-4-yl]-2-methyl-~{N}-[5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyridin-2-yl]benzamide, Programmed cell death 1 ligand 1 著者 Cheng, Y, Xiao, Y.B. 登録日 2023-07-22 公開日 2024-01-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy. J.Med.Chem., 66, 2023
8THG	Cryo-EM structure of Nav1.7 with RLZ 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Fan, X, Huang, J, Yan, N. 登録日 2023-07-16 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8THH	Cryo-EM structure of Nav1.7 with LTG 分子名称: (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... 著者 Fan, X, Huang, J, Yan, N. 登録日 2023-07-16 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8TE6	Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain 分子名称: V-set and immunoglobulin domain-containing protein 4 著者 Abram, T.G, Geisbrecht, B.V. 登録日 2023-07-05 公開日 2023-07-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.251 Å) 主引用文献 New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023
8TE5	Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain 分子名称: V-set and immunoglobulin domain-containing protein 4 著者 Abram, T.G, Geisbrecht, B.V. 登録日 2023-07-05 公開日 2023-07-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.502 Å) 主引用文献 New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023
8TBQ	The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, SNS-101 Fab heavy chain, ... 著者 van der Horst, E.H, Mukherjee, A, Thisted, T. 登録日 2023-06-29 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.593 Å) 主引用文献 The pH-selective anti-VISTA antibody SNS-101 displays a favorable pharmacokinetic and safety profile and promotes anti-tumoral M1 macrophage polarization in PD-1 refractory settings To Be Published
8SZY	Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BMS-986207 Fab Heavy Chain, BMS-986207 light chain, ... 著者 Diong, S.J, Lee, P.S. 登録日 2023-05-30 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT. Mabs, 15, 2023
8P64	Co-crystal structure of PD-L1 with low molecular weight inhibitor 分子名称: Programmed cell death 1 ligand 1, ~{N}-[[1-[(~{E})-2-(2-methyl-3-phenyl-phenyl)ethenyl]-1,2,3,4-tetrazol-5-yl]methyl]ethanamine 著者 Plewka, J, Magiera-Mularz, K, van der Straat, R, Draijer, R, Surmiak, E, Butera, R, Land, L, Musielak, B, Domling, A. 登録日 2023-05-25 公開日 2024-03-06 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.312 Å) 主引用文献 1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists. Rsc Med Chem, 15, 2024
8JEL	Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I 分子名称: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain 著者 Sun, J, Zhang, X.X, Song, J. 登録日 2023-05-16 公開日 2024-02-28 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
8JEO	Crystal structure of TIGIT in complexed with Tiragolumab 分子名称: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain 著者 Sun, J, Zhang, X.X, Song, J. 登録日 2023-05-16 公開日 2024-02-28 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
8JEN	Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II 分子名称: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain 著者 Sun, J, Zhang, X.X, Song, J. 登録日 2023-05-16 公開日 2024-02-28 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
8P1O	Solubilizer tag effect on PD-L1/inhibitor binding properties for m-terphenyl derivatives 分子名称: (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, Programmed cell death 1 ligand 1, ... 著者 Plewka, J, Magiera-Mularz, K, Surmiak, E, Kalinowska-Tluscik, J, Holak, T.A. 登録日 2023-05-12 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives. Acs Med.Chem.Lett., 15, 2024
8JC0	V gamma9 V delta2 TCR and CD3 complex in LMNG 分子名称: CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... 著者 Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-05-10 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 2024
8JCB	Vgamma5 Vdelta1 T cell receptor complex 分子名称: T cell receptor delta variable 1,T cell receptor delta constant, T cell receptor gamma variable 5,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... 著者 Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-05-10 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (9.5 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 2024
8JBV	Extracellular domain of gamma delta TCR 分子名称: T cell receptor delta variable 1,T cell receptor delta constant, T cell receptor gamma variable 5,T cell receptor gamma constant 1 著者 Xin, W, Chi, X, Huang, B, Su, Q, Zhou, Q. 登録日 2023-05-09 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 2024
8JBA	Discovery and Crystallography Study of Novel Oxadiazole Analogs as Small Molecule PD-1/PD-L1 inhibitors 分子名称: (2~{S})-2-[[3-[[5-[(2-methyl-3-phenyl-phenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]methylamino]-3-oxidanyl-propanoic acid, Programmed cell death 1 ligand 1 著者 Cheng, Y, Xiao, Y.B. 登録日 2023-05-08 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J.Med.Chem., 66, 2023

 

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