8R6Q

Co-crystal structure of PD-L1 with low molecular weight inhibitor

Summary for 8R6Q

• Entry DOI: 10.2210/pdb8r6q/pdb
• Descriptor: Programmed cell death 1 ligand 1, (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: pd-l1, immunotherapy, smis, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 30143.57

Authors

Plewka, J.,Surmiak, E.,Magiera-Mularz, K.,Kalinowska-Tluscik, J. (deposition date: 2023-11-22, release date: 2024-01-17, Last modification date: 2024-01-31)

• Primary citation: Surmiak, E.,Zaber, J.,Plewka, J.,Wojtanowicz, G.,Kocik-Krol, J.,Kruc, O.,Muszak, D.,Rodriguez, I.,Musielak, B.,Viviano, M.,Castellano, S.,Skalniak, L.,Magiera-Mularz, K.,Holak, T.A.,Kalinowska-Tluscik, J.; Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives.; Acs Med.Chem.Lett., 15:36-44, 2024; PubMed: 38229762; DOI: 10.1021/acsmedchemlett.3c00306

Experimental method

X-RAY DIFFRACTION (2.17 Å)