2JC9
| Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine | 分子名称: | ADENOSINE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ... | 著者 | Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg, S.L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P. | 登録日 | 2006-12-21 | 公開日 | 2007-01-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition J.Biol.Chem., 282, 2007
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5L50
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5OPM
| Crystal structure of D52N/R238W cN-II mutant bound to dATP and free phosphate | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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5OPP
| Crystal structure of S408R cN-II mutant | 分子名称: | BROMIDE ION, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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5OPK
| Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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5OPN
| Crystal structure of R39Q cN-II mutant | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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5K7Y
| Crystal structure of enzyme in purine metabolism | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL | 著者 | Skerlova, J, Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2016-05-27 | 公開日 | 2016-09-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia. Bmc Biol., 14, 2016
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5OPL
| Crystal structure of K25E cN-II mutant | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION | 著者 | Kugler, M, Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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6DDY
| Crystal structure of the double mutant (D52N/K359Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION | 著者 | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2018-05-10 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34, 2018
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5L4Z
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2XCW
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6DDZ
| Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, Northeast Structural Genomics Target | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... | 著者 | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2018-05-10 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34, 2018
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6DD3
| Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION | 著者 | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L. | 登録日 | 2018-05-09 | 公開日 | 2018-07-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34, 2018
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5OPO
| Crystal structure of R238G cN-II mutant | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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2XJC
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2XJD
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6DE0
| Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the active state | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION | 著者 | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L. | 登録日 | 2018-05-10 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34, 2018
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6DE2
| Crystal structure of the double mutant (D52N/L375F) of the full-length NT5C2 in the active state | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, ... | 著者 | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L. | 登録日 | 2018-05-10 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34, 2018
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2XJF
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2JCM
| Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with beryllium trifluoride | 分子名称: | CYTOSOLIC PURINE 5'-NUCLEOTIDASE, MAGNESIUM ION, SULFATE ION, ... | 著者 | Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P. | 登録日 | 2006-12-27 | 公開日 | 2007-01-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition J.Biol.Chem., 282, 2007
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6DE1
| Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the active state | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION | 著者 | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L. | 登録日 | 2018-05-10 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34, 2018
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2J2C
| Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II) | 分子名称: | CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Loppnau, P, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Nordlund, P. | 登録日 | 2006-08-16 | 公開日 | 2006-09-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition J.Biol.Chem., 282, 2007
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6FIW
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6DDL
| Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the basal state | 分子名称: | Cytosolic purine 5'-nucleotidase, PHOSPHATE ION | 著者 | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L. | 登録日 | 2018-05-10 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34, 2018
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6FIS
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