5OPK

Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate

Summary for 5OPK

• Entry DOI: 10.2210/pdb5opk/pdb
• Descriptor: Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: nucleotidase, relapsed leukemia, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 56757.81

Authors

Hnizda, A.,Pachl, P.,Rezacova, P. (deposition date: 2017-08-10, release date: 2018-06-13, Last modification date: 2024-01-17)

• Primary citation: Hnizda, A.,Fabry, M.,Moriyama, T.,Pachl, P.,Kugler, M.,Brinsa, V.,Ascher, D.B.,Carroll, W.L.,Novak, P.,Zaliova, M.,Trka, J.,Rezacova, P.,Yang, J.J.,Veverka, V.; Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.; Leukemia, 32:1393-1403, 2018; PubMed: 29535428; DOI: 10.1038/s41375-018-0073-5

Experimental method

X-RAY DIFFRACTION (1.74 Å)