5OPK
Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | ASP252 |
| A | TYR253 |
| A | VAL288 |
| A | ASP289 |
| A | GLY310 |
| A | LEU312 |
| A | HOH724 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | TYR434 |
| A | SER439 |
| A | PHE441 |
| A | HIS486 |
| A | GLU487 |
| A | GLU378 |
| A | TRP382 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | PHE283 |
| A | ASP284 |
| A | ILE286 |
| A | GLN322 |
| A | HIS323 |
| A | GLY324 |
| A | ILE325 |
| A | HOH653 |
| A | HOH669 |
| A | HOH823 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ARG28 |
| A | ARG34 |
| A | VAL35 |
| A | VAL37 |
| A | TYR471 |
| A | TYR475 |
| A | HOH713 |
| A | HOH790 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | THR97 |
| A | GLU374 |
| A | GLU378 |
| A | TYR434 |
| A | GLY438 |
| A | HOH709 |
| A | HOH730 |
| A | HOH792 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | THR56 |
| A | LEU57 |
| A | VAL59 |
| A | VAL227 |
| A | ASP229 |
| A | LEU232 |
| A | PHE465 |
| A | HOH610 |
| A | HOH617 |
| A | HOH630 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | TYR151 |
| A | ILE152 |
| A | ASN154 |
| A | HIS352 |
| A | PHE354 |
| A | DTP514 |
| A | HOH726 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 508 |
| Chain | Residue |
| A | TYR210 |
| A | ASN250 |
| A | PO4510 |
| A | HOH737 |
| A | HOH763 |
| A | HOH776 |
| A | HOH842 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 509 |
| Chain | Residue |
| A | ASP257 |
| A | THR261 |
| A | PRO278 |
| A | GLN280 |
| A | HOH640 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 A 510 |
| Chain | Residue |
| A | ASN52 |
| A | MET53 |
| A | ASP54 |
| A | THR249 |
| A | ASN250 |
| A | SER251 |
| A | LYS292 |
| A | GOL508 |
| A | MG512 |
| A | HOH631 |
| A | HOH641 |
| A | HOH788 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 512 |
| Chain | Residue |
| A | ASN52 |
| A | ASP54 |
| A | ASP351 |
| A | PO4510 |
| A | HOH631 |
| A | HOH641 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 513 |
| Chain | Residue |
| A | LYS362 |
| A | DTP514 |
| A | DTP514 |
| A | HOH605 |
| site_id | AD4 |
| Number of Residues | 20 |
| Details | binding site for residue DTP A 514 |
| Chain | Residue |
| A | ARG456 |
| A | ARG456 |
| A | TYR457 |
| A | GOL507 |
| A | MG513 |
| A | MG513 |
| A | HOH604 |
| A | HOH605 |
| A | HOH605 |
| A | HOH608 |
| A | HOH615 |
| A | HOH645 |
| A | ARG144 |
| A | ASP145 |
| A | ASN154 |
| A | PHE354 |
| A | LEU358 |
| A | LYS362 |
| A | LYS362 |
| A | GLN453 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:21396942 |
| Chain | Residue | Details |
| A | ASN52 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:21396942 |
| Chain | Residue | Details |
| A | ASP54 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2J2C, ECO:0007744|PDB:2JC9, ECO:0007744|PDB:2JCM, ECO:0007744|PDB:2XCV, ECO:0007744|PDB:2XCW, ECO:0007744|PDB:2XJB, ECO:0007744|PDB:2XJC, ECO:0007744|PDB:2XJD, ECO:0007744|PDB:2XJE |
| Chain | Residue | Details |
| A | ASN52 | |
| A | ASP54 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XJB |
| Chain | Residue | Details |
| A | ARG144 | |
| A | SER464 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XJC |
| Chain | Residue | Details |
| A | ASN154 | |
| A | LYS362 | |
| A | TYR461 | |
| A | PHE465 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XCV, ECO:0007744|PDB:2XCW |
| Chain | Residue | Details |
| A | ARG202 | |
| A | ASP206 | |
| A | LYS215 | |
| A | THR249 | |
| A | ASN250 | |
| A | SER251 | |
| A | LYS292 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2J2C, ECO:0007744|PDB:2JC9, ECO:0007744|PDB:2JCM |
| Chain | Residue | Details |
| A | ASP351 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0007744|PDB:2JC9 |
| Chain | Residue | Details |
| A | GLY444 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | VAL426 |
