Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6DDY

Crystal structure of the double mutant (D52N/K359Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target

Summary for 6DDY
Entry DOI10.2210/pdb6ddy/pdb
DescriptorCytosolic purine 5'-nucleotidase, PHOSPHATE ION, GLYCEROL, ... (4 entities in total)
Functional Keywordsstructural genomics, psi-biology, northeast structural genomics consortium, nesg, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight64142.77
Authors
Primary citationDieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A.
Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34:136-147.e6, 2018
Cited by
PubMed: 29990496
DOI: 10.1016/j.ccell.2018.06.003
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.803 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon