6DDY

Crystal structure of the double mutant (D52N/K359Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000255	biological_process	allantoin metabolic process
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006202	biological_process	GMP catabolic process to guanine
A	0006204	biological_process	IMP catabolic process
A	0008253	molecular_function	5'-nucleotidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0043605	biological_process	amide catabolic process
A	0046037	biological_process	GMP metabolic process
A	0046038	biological_process	GMP catabolic process
A	0046040	biological_process	IMP metabolic process
A	0046054	biological_process	dGMP metabolic process
A	0046055	biological_process	dGMP catabolic process
A	0046085	biological_process	adenosine metabolic process
A	0046872	molecular_function	metal ion binding
A	0050146	molecular_function	nucleoside phosphotransferase activity
A	0050689	biological_process	negative regulation of defense response to virus by host
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	0140374	biological_process	antiviral innate immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 A 601

Chain	Residue
A	ASN52
A	MET53
A	ASP54
A	THR249
A	ASN250
A	LYS292

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 602

Chain	Residue
A	ASP289
A	GLY310
A	LEU312
A	ASP252
A	TYR253
A	VAL288

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---