6DE2
Crystal structure of the double mutant (D52N/L375F) of the full-length NT5C2 in the active state
Summary for 6DE2
Entry DOI | 10.2210/pdb6de2/pdb |
Descriptor | Cytosolic purine 5'-nucleotidase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 67802.41 |
Authors | Forouhar, F.,Dieck, C.L.,Tzoneva, G.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Ferrando, A.A.,Tong, L. (deposition date: 2018-05-10, release date: 2018-07-04, Last modification date: 2023-10-11) |
Primary citation | Dieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34:136-147.e6, 2018 Cited by PubMed: 29990496DOI: 10.1016/j.ccell.2018.06.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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