6DE2
Crystal structure of the double mutant (D52N/L375F) of the full-length NT5C2 in the active state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytosolic purine 5'-nucleotidase | polymer | 579 | 66989.8 | 1 | UniProt (P49902) Pfam (PF05761) | Homo sapiens (Human) | Cytosolic 5'-nucleotidase II |
| 2 | B (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | E, F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | H (A) | water | water | 18.0 | 439 | Chemie (HOH) |
Sequence modifications
A: 1 - 561 (UniProt: P49902)
| PDB | External Database | Details |
|---|---|---|
| Gly -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 52 | Asp 52 | engineered mutation |
| Phe 375 | Leu 375 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 66989.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 812.7 | |
| All* | Total formula weight | 67802.4 |
