6DD3

Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state

Summary for 6DD3

Entry DOI	10.2210/pdb6dd3/pdb
Descriptor	Cytosolic purine 5'-nucleotidase, PHOSPHATE ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	62574.78
Authors	Forouhar, F.,Dieck, C.L.,Tzoneva, G.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Ferrando, A.A.,Tong, L. (deposition date: 2018-05-09, release date: 2018-07-04, Last modification date: 2024-03-13)
Primary citation	Dieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34:136-147.e6, 2018 Cited by PubMed: 29990496 DOI: 10.1016/j.ccell.2018.06.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation