3G91
| 1.2 Angstrom structure of the exonuclease III homologue Mth0212 | 分子名称: | DI(HYDROXYETHYL)ETHER, Exodeoxyribonuclease, GLYCEROL, ... | 著者 | Lakomek, K, Dickmanns, A, Ficner, R. | 登録日 | 2009-02-12 | 公開日 | 2010-03-09 | 最終更新日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | 主引用文献 | Crystal Structure Analysis of DNA Uridine Endonuclease Mth212 Bound to DNA. J.Mol.Biol., 399, 2010
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7TC3
| Human APE1 in the apo form | 分子名称: | 1,2-ETHANEDIOL, DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial | 著者 | Pidugu, L.S, Pozharski, E, Drohat, A.C. | 登録日 | 2021-12-22 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.252 Å) | 主引用文献 | Characterizing inhibitors of human AP endonuclease 1. Plos One, 18, 2023
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4RUW
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4QHE
| Crystal structure of Mg2+ bound human APE1 | 分子名称: | 1,2-ETHANEDIOL, DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION | 著者 | He, H, Chen, Q, Georgiadis, M.M. | 登録日 | 2014-05-28 | 公開日 | 2014-11-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I. Biochemistry, 53, 2014
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2DDR
| Crystal structure of sphingomyelinase from Bacillus cereus with calcium ion | 分子名称: | CALCIUM ION, Sphingomyelin phosphodiesterase | 著者 | Ago, H, Oda, M, Takahashi, M, Tsuge, H, Ochi, S, Katunuma, N, Miyano, M, Sakurai, J, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2006-02-02 | 公開日 | 2006-05-02 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural Basis of the Sphingomyelin Phosphodiesterase Activity in Neutral Sphingomyelinase from Bacillus cereus. J.Biol.Chem., 281, 2006
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7TC2
| Human APE1 in complex with 5-nitroindole-2-carboxylic acid | 分子名称: | 1,2-ETHANEDIOL, 5-nitro-1H-indole-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | 著者 | Pidugu, L.S, Pozharski, E, Drohat, A.C. | 登録日 | 2021-12-22 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Characterizing inhibitors of human AP endonuclease 1. Plos One, 18, 2023
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5HT2
| Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with 1-N6-etheno-adenine | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DNA, ... | 著者 | Schellenberg, M.J, Vilas, C.K, Williams, R.S. | 登録日 | 2016-01-26 | 公開日 | 2016-04-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
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5J8N
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6MKK
| Crystallographic solvent mapping analysis of DMSO/Mg bound to APE1 | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, DNA-(apurinic or apyrimidinic site) lyase, ... | 著者 | Georgiadis, M.M, He, H, Chen, Q. | 登録日 | 2018-09-25 | 公開日 | 2019-01-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.442 Å) | 主引用文献 | Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. J. Med. Chem., 62, 2019
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6RW0
| Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase | 分子名称: | GLYCEROL, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Kroupova, A, Jinek, M. | 登録日 | 2019-06-03 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Science, 369, 2020
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6MK3
| Crystallographic solvent mapping analysis of DMSO bound to APE1 | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, DNA-(apurinic or apyrimidinic site) lyase | 著者 | Georgiadis, M.M, He, H, Chen, Q. | 登録日 | 2018-09-24 | 公開日 | 2019-01-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.478 Å) | 主引用文献 | Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. J. Med. Chem., 62, 2019
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6BT1
| Structure of the human Nocturnin catalytic domain | 分子名称: | MAGNESIUM ION, Nocturnin | 著者 | Abshire, E.T, Chasseur, J, Del Rizzo, P, Trievel, R. | 登録日 | 2017-12-04 | 公開日 | 2018-05-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells. Nucleic Acids Res., 46, 2018
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6LPM
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4GZ1
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2JC5
| Apurinic Apyrimidinic (AP) endonuclease (NApe) from Neisseria Meningitidis | 分子名称: | 1,4-DIETHYLENE DIOXIDE, BICINE, EXODEOXYRIBONUCLEASE, ... | 著者 | Carpenter, E.P, Corbett, A, Thomson, H, Adacha, J, Jensen, K, Bergeron, J, Kasampalidis, I, Exley, R, Winterbotham, M, Tang, C, Baldwin, G.S, Freemont, P. | 登録日 | 2006-12-19 | 公開日 | 2007-03-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Ap Endonuclease Paralogues with Distinct Activities in DNA Repair and Bacterial Pathogenesis. Embo J., 26, 2007
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6WCD
| Crystal Structure of Xenopus laevis APE2 Catalytic Domain | 分子名称: | 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Wojtaszek, J.L, Wallace, B.D, Williams, R.S. | 登録日 | 2020-03-30 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Mol.Cell, 78, 2020
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5INL
| Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with deoxyadenosine | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DNA (5'-D(P*AP*CP*GP*AP*AP*TP*TP*CP*G)-3'), ... | 著者 | Schellenberg, M.J, Vilas, C.K, Williams, R.S. | 登録日 | 2016-03-07 | 公開日 | 2016-04-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.551 Å) | 主引用文献 | Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
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5DFF
| Human APE1 product complex | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Freudenthal, B.D, Wilson, S.H. | 登録日 | 2015-08-26 | 公開日 | 2015-10-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Capturing snapshots of APE1 processing DNA damage. Nat.Struct.Mol.Biol., 22, 2015
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6BOW
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3L1W
| The crystal structure of a functionally unknown conserved protein from Enterococcus faecalis V583 | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, SULFATE ION, ... | 著者 | Tan, K, Rakowski, E, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2009-12-14 | 公開日 | 2010-01-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The crystal structure of a functionally unknown conserved protein from Enterococcus faecalis V583 To be Published
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7MEV
| Human Apex/Ref1 monomer with C138A mutation | 分子名称: | DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial, GLYCEROL, ... | 著者 | Nam, Y.W, Yang, S. | 登録日 | 2021-04-07 | 公開日 | 2022-04-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma To Be Published
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3W2X
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4PUQ
| Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+ | 分子名称: | ACETATE ION, DNA/RNA hybrid, GLYCEROL, ... | 著者 | Schellenberg, M.J, Williams, R.S. | 登録日 | 2014-03-13 | 公開日 | 2014-05-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2). J.Biol.Chem., 289, 2014
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6CA4
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5DFI
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