6CA4
Crystal structure of humanized D. rerio TDP2 by 14 mutations
Summary for 6CA4
Entry DOI | 10.2210/pdb6ca4/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 2, MAGNESIUM ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | tdp2, hydrolase |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 3 |
Total formula weight | 85923.11 |
Authors | Shi, K.,Aihrara, H. (deposition date: 2018-01-29, release date: 2018-05-02, Last modification date: 2023-10-04) |
Primary citation | Ribeiro, C.J.A.,Kankanala, J.,Shi, K.,Kurahashi, K.,Kiselev, E.,Ravji, A.,Pommier, Y.,Aihara, H.,Wang, Z. New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2). Eur J Pharm Sci, 118:67-79, 2018 Cited by PubMed: 29574079DOI: 10.1016/j.ejps.2018.03.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.623 Å) |
Structure validation
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