6CA4

Crystal structure of humanized D. rerio TDP2 by 14 mutations

Summary for 6CA4

Entry DOI	10.2210/pdb6ca4/pdb
Descriptor	Tyrosyl-DNA phosphodiesterase 2, MAGNESIUM ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	tdp2, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	3
Total formula weight	85923.11
Authors	Shi, K.,Aihrara, H. (deposition date: 2018-01-29, release date: 2018-05-02, Last modification date: 2023-10-04)
Primary citation	Ribeiro, C.J.A.,Kankanala, J.,Shi, K.,Kurahashi, K.,Kiselev, E.,Ravji, A.,Pommier, Y.,Aihara, H.,Wang, Z. New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2). Eur J Pharm Sci, 118:67-79, 2018 Cited by PubMed: 29574079 DOI: 10.1016/j.ejps.2018.03.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.623 Å)

Structure validation