6MK3

Crystallographic solvent mapping analysis of DMSO bound to APE1

Summary for 6MK3

Entry DOI	10.2210/pdb6mk3/pdb
Descriptor	DNA-(apurinic or apyrimidinic site) lyase, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	apurinic/apyrimidinic endonuclease, dna repair, abasic site, solvent mapping, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32353.85
Authors	Georgiadis, M.M.,He, H.,Chen, Q. (deposition date: 2018-09-24, release date: 2019-01-30, Last modification date: 2024-03-13)
Primary citation	Trilles, R.,Beglov, D.,Chen, Q.,He, H.,Wireman, R.,Reed, A.,Chennamadhavuni, S.,Panek, J.S.,Brown, L.E.,Vajda, S.,Porco Jr., J.A.,Kelley, M.R.,Georgiadis, M.M. Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. J. Med. Chem., 62:1971-1988, 2019 Cited by PubMed: 30653918 DOI: 10.1021/acs.jmedchem.8b01529 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.478 Å)

Structure validation