6WCD

Crystal Structure of Xenopus laevis APE2 Catalytic Domain

Summary for 6WCD

Entry DOI	10.2210/pdb6wcd/pdb
Related	5U6Z
Descriptor	DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total)
Functional Keywords	nuclease, dna repair, hydrolase
Biological source	Xenopus laevis (African clawed frog)
Total number of polymer chains	1
Total formula weight	40407.58
Authors	Wojtaszek, J.L.,Wallace, B.D.,Williams, R.S. (deposition date: 2020-03-30, release date: 2020-05-06, Last modification date: 2023-10-18)
Primary citation	Alvarez-Quilon, A.,Wojtaszek, J.L.,Mathieu, M.C.,Patel, T.,Appel, C.D.,Hustedt, N.,Rossi, S.E.,Wallace, B.D.,Setiaputra, D.,Adam, S.,Ohashi, Y.,Melo, H.,Cho, T.,Gervais, C.,Munoz, I.M.,Grazzini, E.,Young, J.T.F.,Rouse, J.,Zinda, M.,Williams, R.S.,Durocher, D. Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Mol.Cell, 78:1152-, 2020 Cited by PubMed: 32516598 DOI: 10.1016/j.molcel.2020.05.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation