6WCD
Crystal Structure of Xenopus laevis APE2 Catalytic Domain
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | ASN9 |
| A | GLU34 |
| A | HOH515 |
| A | HOH517 |
| A | HOH561 |
| A | HOH657 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MES A 402 |
| Chain | Residue |
| A | GLU327 |
| A | LYS334 |
| A | HOH841 |
| A | LEU287 |
| A | ASP288 |
| A | PHE306 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue BU1 A 403 |
| Chain | Residue |
| A | MET1 |
| A | ASP28 |
| A | LEU41 |
| A | SER75 |
| A | GLN310 |
| A | PRO311 |
| A | HOH521 |
| A | HOH544 |
| A | HOH631 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | LYS19 |
| A | GLU50 |
| A | GLY51 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue BU1 A 405 |
| Chain | Residue |
| A | ARG12 |
| A | ALA13 |
| A | ARG15 |
| A | HOH529 |
| A | HOH543 |
| A | HOH556 |
| A | HOH822 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue BU1 A 406 |
| Chain | Residue |
| A | GLU107 |
| A | GLU108 |
| A | LYS157 |
| A | ASN185 |
| A | THR186 |
| A | ASN205 |
| A | GLY207 |
Functional Information from PROSITE/UniProt
| site_id | PS00726 |
| Number of Residues | 10 |
| Details | AP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. ADIICLQETK |
| Chain | Residue | Details |
| A | ALA27-LYS36 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Claspin-like CKB motif","evidences":[{"source":"PubMed","id":"23754435","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P27695","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"32516598","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00764","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32516598","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WCD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00764","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32516598","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WCD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00764","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P27695","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"UniProtKB","id":"P27695","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with DNA substrate","evidences":[{"source":"UniProtKB","id":"P27695","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
