PDB: 74 件ウェブページステータス検索Chemie searchBIRD

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4TMP	Crystal structure of AF9 YEATS bound to H3K9ac peptide 分子名称: 1,2-ETHANEDIOL, ALA-ARG-THR-LYS-GLN-THR-ALA-ARG-ALY-SER-THR, Protein AF-9 著者 Li, H, Li, Y, Wang, H, Ren, Y. 登録日 2014-06-02 公開日 2014-11-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation. Cell, 159, 2014
6AXJ	Crystal structure of the Yaf9 YEATS domain bound to H3K27ac 分子名称: ALY-SER-ALA-PRO-ALA, GLYCEROL, Protein AF-9 homolog, ... 著者 Klein, B.J, Kutateladze, T.G. 登録日 2017-09-06 公開日 2017-11-22 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.379 Å) 主引用文献 Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain. Nucleic Acids Res., 46, 2018
8DKB	Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b 分子名称: N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide, YEATS domain-containing protein 4 著者 Dias, J.M, Byrnes, L.J, Varghese, A.H. 登録日 2022-07-05 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. J.Med.Chem., 66, 2023
3FK3	Structure of the Yeats Domain, Yaf9 分子名称: Protein AF-9 homolog 著者 Wang, A.Y, Schulze, J.M, Skordalakes, E, Berger, J.M, Rine, J, Kobor, M.S. 登録日 2008-12-15 公開日 2009-10-27 最終更新日 2021-03-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation Proc.Natl.Acad.Sci.USA, 106, 2009
5D7E	Crystal structure of Taf14 YEATS domain in complex with H3K9ac 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, H3K9ac, ... 著者 Andrews, F.H, Shanle, E.K, Strahl, B.D, Kutateladze, T.G. 登録日 2015-08-13 公開日 2015-09-23 最終更新日 2019-12-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Genes Dev., 29, 2015
5IQL	Crystal structure of YEATS2 YEATS bound to H3K27cr peptide 分子名称: Histone H3.1, YEATS domain-containing protein 2 著者 Li, H, Zhao, D, Guan, H. 登録日 2016-03-11 公開日 2016-07-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 YEATS2 is a selective histone crotonylation reader. Cell Res., 26, 2016
5J9S	ENL YEATS in complex with histone H3 acetylation at K27 分子名称: H3K27ac peptide from Histone H3.1, Protein ENL, SULFATE ION 著者 Li, Y, Li, H. 登録日 2016-04-11 公開日 2017-03-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia Nature, 543, 2017
8PJ7	MLLT3 in complex with compound PFI-6 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C. 登録日 2023-06-22 公開日 2023-11-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98, 2023
8PJI	MLLT1 in complex with compound 10a 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Protein ENL, ... 著者 Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C. 登録日 2023-06-23 公開日 2023-11-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98, 2023
7B0T	Crystal structure of MLLT1 YEATS domain T3 mutant in complex with benzimidazole-amide based compound 1 分子名称: 1,2-ETHANEDIOL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, Protein ENL 著者 Ni, X, Chaikuad, A, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-11-21 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. Acs Chem.Biol., 16, 2021
7B10	Crystal structure of MLLT1 YEATS domain T1 mutant in complex with benzimidazole-amide based compound 1 分子名称: 1,2-ETHANEDIOL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, IODIDE ION, ... 著者 Chaikuad, A, Ni, X, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-11-23 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. Acs Chem.Biol., 16, 2021
3QRL	Crystal Structure of the Taf14 YEATS domain 分子名称: TRIETHYLENE GLYCOL, Transcription initiation factor TFIID subunit 14 著者 Simpson, P.J, Warren, A.J. 登録日 2011-02-18 公開日 2012-02-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of the Taf14 YEATS domain To be Published
3RLS	Crystal structure of yeast AF-9 homolog protein Yaf9 分子名称: Protein AF-9 homolog 著者 Chen, S.D, Wu, L.J, Liu, Y.F. 登録日 2011-04-20 公開日 2011-05-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of yeast AF-9 homolog protein yaf9 To be Published
5HJB	AF9 YEATS in complex with histone H3 Crotonylation at K9 分子名称: Protein AF-9, peptide of Histone H3.1 著者 Li, Y.Y, Zhao, D, Guan, H.P, Li, H.T. 登録日 2016-01-12 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain Mol.Cell, 62, 2016
5HJD	AF9 YEATS in complex with histone H3 Crotonylation at K18 分子名称: COPPER (II) ION, Protein AF-9, SULFATE ION, ... 著者 Li, Y.Y, Zhao, D, Guan, H.P, Li, H.T. 登録日 2016-01-13 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.806 Å) 主引用文献 Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Mol.Cell, 62, 2016
5IOK	Crystal structure of Taf14 YEATS domain in complex with histone H3K9cr 分子名称: (ACE)QTAR(KCR)ST, DI(HYDROXYETHYL)ETHER, Transcription initiation factor TFIID subunit 14 著者 Andrews, F.H, Kuateladze, T.G. 登録日 2016-03-08 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 The Taf14 YEATS domain is a reader of histone crotonylation. Nat.Chem.Biol., 12, 2016
2L7E	The structure of a domain from yeast 分子名称: Transcription initiation factor TFIID subunit 14 著者 Zhang, W, Zhang, J, Tu, X. 登録日 2010-12-08 公開日 2011-03-23 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 solution structure of Taf14 YEATS domain To be Published
2NDF	Solution NMR structures of AF9 yeats domain in complex with histon H3 acetylation at K18 分子名称: Histone H3 peptide, Protein AF-9 著者 Zeng, L, Zhou, M. 登録日 2016-05-19 公開日 2016-09-07 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain. Structure, 24, 2016
2NDG	Solution NMR structures of AF9 yeats domain in complex with histone H3 crotonylation at K18 分子名称: Histone H3 peptide, Protein AF-9 著者 Zeng, L, Zhou, M. 登録日 2016-05-19 公開日 2016-09-07 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain. Structure, 24, 2016
5R68	XChem group deposition -- Crystal Structure of human YEATS4 in complex with FM000199e 分子名称: (1-methylbenzotriazol-5-yl)methanol, 1,2-ETHANEDIOL, YEATS domain-containing protein 4 著者 Raux, B, Krojer, T, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Huber, K.V.M. 登録日 2020-02-29 公開日 2020-12-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 XChem group deposition To Be Published
5R69	XChem group deposition -- Crystal Structure of human YEATS4 in complex with XS038644e 分子名称: 1,2-ETHANEDIOL, YEATS domain-containing protein 4, ~{N}-(5-oxidanylidene-7,8-dihydro-6~{H}-naphthalen-2-yl)ethanamide 著者 Raux, B, Krojer, T, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Huber, K.V.M. 登録日 2020-02-29 公開日 2020-12-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 XChem group deposition To Be Published
8I60	Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr 分子名称: ALA-ARG-KCR-SER-ALA-PRO, GLYCEROL, SULFATE ION, ... 著者 Konuma, T, Zhou, M.-M. 登録日 2023-01-26 公開日 2023-07-26 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Mol.Cell, 83, 2023
8IJ0	Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide 分子名称: GLYCEROL, Histone H3.1, PENTAETHYLENE GLYCOL, ... 著者 Kikuchi, M, Umehara, T. 登録日 2023-02-24 公開日 2023-11-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
5VNA	Crystal structure of human YEATS domain 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, SULFATE ION, ... 著者 Cho, H.J, Cierpicki, T. 登録日 2017-04-29 公開日 2018-09-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode. ACS Chem. Biol., 13, 2018
5VNB	YEATS in complex with histone H3 分子名称: 1,2-ETHANEDIOL, H3K23acK27ac peptide, SULFATE ION, ... 著者 Cho, H.J, Cierpicki, T. 登録日 2017-04-29 公開日 2018-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode. ACS Chem. Biol., 13, 2018

 

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