7B10

Crystal structure of MLLT1 YEATS domain T1 mutant in complex with benzimidazole-amide based compound 1

Summary for 7B10

• Entry DOI: 10.2210/pdb7b10/pdb
• Descriptor: Protein ENL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, IODIDE ION, ... (5 entities in total)
• Functional Keywords: t1 mutant, structural genomics, structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 19874.40

Authors

Chaikuad, A.,Ni, X.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-23, release date: 2021-02-17, Last modification date: 2024-01-31)

• Primary citation: Ni, X.,Londregan, A.T.,Owen, D.R.,Knapp, S.,Chaikuad, A.; Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants.; Acs Chem.Biol., 16:571-578, 2021; PubMed: 33749253; DOI: 10.1021/acschembio.0c00960

Experimental method

X-RAY DIFFRACTION (1.92 Å)