7B10
Crystal structure of MLLT1 YEATS domain T1 mutant in complex with benzimidazole-amide based compound 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue GKT A 201 |
| Chain | Residue |
| A | PHE28 |
| A | ALA79 |
| A | GLY80 |
| A | TYR136 |
| A | IOD202 |
| A | HOH315 |
| A | HOH325 |
| A | HIS56 |
| A | SER58 |
| A | PHE59 |
| A | PRO60 |
| A | GLU75 |
| A | SER76 |
| A | GLY77 |
| A | TYR78 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 202 |
| Chain | Residue |
| A | GKT201 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 203 |
| Chain | Residue |
| A | VAL9 |
| A | ARG10 |
| A | CYS42 |
| A | ILE44 |
| A | PHE47 |
| A | ALA141 |
| A | GLY142 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 204 |
| Chain | Residue |
| A | HIS15 |
| A | PHE35 |
| A | GLU109 |
| A | ASN118 |
| A | HIS119 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 205 |
| Chain | Residue |
| A | ARG16 |
| A | ASP31 |
| A | MET33 |
| A | EDO213 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 206 |
| Chain | Residue |
| A | GLY80 |
| A | PHE81 |
| A | ASP103 |
| A | PHE105 |
| A | LEU106 |
| A | HIS119 |
| A | HOH346 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 207 |
| Chain | Residue |
| A | ARG20 |
| A | LYS21 |
| A | LYS22 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 208 |
| Chain | Residue |
| A | THR24 |
| A | THR25 |
| A | HOH311 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 209 |
| Chain | Residue |
| A | PHE35 |
| A | ARG37 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 210 |
| Chain | Residue |
| A | GLN45 |
| A | GLU74 |
| A | LYS90 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 211 |
| Chain | Residue |
| A | LYS50 |
| A | ARG63 |
| A | LYS67 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 212 |
| Chain | Residue |
| A | THR126 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 213 |
| Chain | Residue |
| A | ARG16 |
| A | ALA17 |
| A | GLN18 |
| A | ASN111 |
| A | HIS116 |
| A | ASN118 |
| A | EDO205 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Region: {"description":"Acylated histone binding","evidences":[{"source":"PubMed","id":"28241141","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5J9S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Acylated histone binding","evidences":[{"source":"PubMed","id":"28241141","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5J9S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
