7B10
Crystal structure of MLLT1 YEATS domain T1 mutant in complex with benzimidazole-amide based compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein ENL | polymer | 157 | 18590.4 | 1 | UniProt (Q03111) Pfam (PF03366) | Homo sapiens (Human) | YEATS domain-containing protein 1 |
| 2 | B (A) | 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide | non-polymer | 474.3 | 1 | Chemie (GKT) | |||
| 3 | C (A) | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) | |||
| 4 | D, E, F, G, H... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 5 | O (A) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A: 1 - 151 (UniProt: Q03111)
| PDB | External Database | Details |
|---|---|---|
| Asn 115 | - | insertion |
| His 116 | - | insertion |
| Leu 117 | - | insertion |
| His 152 | - | expression tag |
| His 153 | - | expression tag |
| His 154 | - | expression tag |
| His 155 | - | expression tag |
| His 156 | - | expression tag |
| His 157 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18590.4 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1284.0 | |
| All* | Total formula weight | 19874.4 |
