4LRH
| Crystal structure of human folate receptor alpha in complex with folic acid | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, Folate receptor alpha | 著者 | Ke, J, Chen, C, Zhou, X.E, Yi, W, Brunzelle, J.S, Li, J, Young, E.-L, Xu, H.E, Melcher, K. | 登録日 | 2013-07-19 | 公開日 | 2013-07-31 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for molecular recognition of folic acid by folate receptors. Nature, 500, 2013
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6HCE
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4KN0
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7PGK
| HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Hedgehog-interacting protein | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2021-12-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGL
| HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form | 分子名称: | Hedgehog-interacting protein | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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5EJN
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5F4Q
| Crystal structure of the human egg surface protein Juno | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Aydin, H, Sultana, A, Lee, J.E. | 登録日 | 2015-12-03 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. Nature, 534, 2016
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4KM7
| Human folate receptor alpha (FOLR1) at acidic pH, triclinic form | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Folate receptor alpha, POTASSIUM ION | 著者 | Kovach, A.R, Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KM6
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4KN1
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4KMX
| Human folate receptor alpha (FOLR1) at acidic pH, hexagonal form | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KMY
| Human folate receptor beta (FOLR2) at neutral pH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Folate receptor beta, POTASSIUM ION | 著者 | Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KMZ
| Human folate receptor beta (FOLR2) in complex with the folate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, FOLIC ACID, ... | 著者 | Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KN2
| Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, CHLORIDE ION, ... | 著者 | Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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5IZQ
| Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183 | 分子名称: | Folate receptor alpha, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid | 著者 | Ke, J, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-03-25 | 公開日 | 2016-08-10 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J.Med.Chem., 59, 2016
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5JKA
| Crystal structure of human JUNO (crystal form 1) | 分子名称: | CHLORIDE ION, Sperm-egg fusion protein Juno, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2016-04-26 | 公開日 | 2016-06-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization Nature, 534, 2016
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5JKB
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5JYJ
| Crystal structure of mouse JUNO | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sperm-egg fusion protein Juno | 著者 | Kato, K, Nishimasu, H, Morita, J, Ishitani, R, Nureki, O. | 登録日 | 2016-05-14 | 公開日 | 2017-05-24 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the egg IZUMO1 receptor JUNO To Be Published
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5F4E
| Crystal structure of the human sperm Izumo1 and egg Juno complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Aydin, H, Sultana, A, Lee, J.E. | 登録日 | 2015-12-03 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. Nature, 534, 2016
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5JKC
| Crystal structure of human IZUMO1-JUNO complex (crystal form 1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2016-04-26 | 公開日 | 2016-06-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization Nature, 534, 2016
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5JKD
| Crystal structure of human IZUMO1-JUNO complex (crystal form 2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2016-04-26 | 公開日 | 2016-06-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization Nature, 534, 2016
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5JKE
| Crystal structure of human IZUMO1-JUNO complex (crystal form 3) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2016-04-26 | 公開日 | 2016-06-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization Nature, 534, 2016
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