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4KN1

Human folate receptor beta (FOLR2) in complex with the antifolate aminopterin

Summary for 4KN1
Entry DOI10.2210/pdb4kn1/pdb
Related4KM6 4KM7 4KMX 4KMY 4KMZ 4KN0 4KN2
DescriptorFolate receptor beta, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopterin, ... (6 entities in total)
Functional Keywordsfolate receptor beta, folr2, folate receptor, folic acid, folates, 5-methyltetrahydrofolate, antifolates, folate-conjugates, gpi-anchored protein on eukaryotic membrane, transport protein, membrane protein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight25194.40
Authors
Wibowo, A.S.,Dann III, C.E. (deposition date: 2013-05-08, release date: 2013-08-07, Last modification date: 2023-09-20)
Primary citationWibowo, A.S.,Singh, M.,Reeder, K.M.,Carter, J.J.,Kovach, A.R.,Meng, W.,Ratnam, M.,Zhang, F.,Dann, C.E.
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
Proc.Natl.Acad.Sci.USA, 110:15180-15188, 2013
Cited by
PubMed: 23934049
DOI: 10.1073/pnas.1308827110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.301 Å)
Structure validation

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