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5U3A
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Ultra High Resolution Crystal Structure of Human Pancreatic Alpha Amylase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Caner, S, Brayer, G.D.
登録日2016-12-01
公開日2017-12-06
最終更新日2022-04-27
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic alpha-Amylase.
Acs Chem.Biol., 14, 2019
4X9Y
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Wild-Type Human Pancreatic Alpha-Amylase at True Atomic Resolution (1.07 A)
分子名称: CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase
著者Caner, S, Brayer, G.D.
登録日2014-12-11
公開日2014-12-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Wild-Type Human Pancreatic Alpha-Amylase at True Atomic Resolution (1.07 A)
To be published
6OCN
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Montbretin A analogue M06-MbA in complex with Human pancreatic alpha-amylase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Caner, S, Brayer, G.D.
登録日2019-03-25
公開日2020-02-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.147 Å)
主引用文献Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic alpha-amylase.
Chem Sci, 10, 2019
4GQR
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Human Pancreatic alpha-amylase in complex with myricetin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CALCIUM ION, ...
著者Williams, L.K, Brayer, G.D.
登録日2012-08-23
公開日2012-10-24
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.
J.Med.Chem., 55, 2012
5EMY
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Human Pancreatic Alpha-Amylase in complex with the mechanism based inactivator glucosyl epi-cyclophellitol
分子名称: (1R,2R,3S,5R,6S)-2,3,5-trihydroxy-6-(hydroxymethyl)cyclohexyl alpha-D-glucopyranoside, CALCIUM ION, CHLORIDE ION, ...
著者Caner, S, Brayer, G.D.
登録日2015-11-06
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.231 Å)
主引用文献Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic alpha-amylase.
Febs Lett., 590, 2016
6M4K
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X-ray crystal structure of wild type alpha-amylase I from Eisenia fetida
分子名称: ACETATE ION, Alpha-amylase, CALCIUM ION, ...
著者Hirano, Y, Tsukamoto, K, Ariki, S, Naka, Y, Ueda, M, Tamada, T.
登録日2020-03-07
公開日2020-09-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献X-ray crystallographic structural studies of alpha-amylase I from Eisenia fetida.
Acta Crystallogr D Struct Biol, 76, 2020
6OBX
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Montbretin A analogue M10-MbA in complex with Human pancreatic alpha-amylase
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Caner, S, Brayer, G.D.
登録日2019-03-21
公開日2020-02-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic alpha-amylase.
Chem Sci, 10, 2019
4GQQ
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Human pancreatic alpha-amylase with bound ethyl caffeate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Williams, L.K, Brayer, G.D.
登録日2012-08-23
公開日2012-10-24
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.
J.Med.Chem., 55, 2012
4W93
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Human pancreatic alpha-amylase in complex with montbretin A
分子名称: CALCIUM ION, CHLORIDE ION, Montbretin A, ...
著者Williams, L.K, Caner, S, Brayer, G.D.
登録日2014-08-27
公開日2015-07-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.352 Å)
主引用文献The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif.
Nat.Chem.Biol., 11, 2015
1HX0
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Structure of pig pancreatic alpha-amylase complexed with the "truncate" acarbose molecule (pseudotrisaccharide)
分子名称: 1,2-ETHANEDIOL, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ALPHA AMYLASE (PPA), ...
著者Qian, M, Payan, F.
登録日2001-01-11
公開日2001-08-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Enzyme-catalyzed condensation reaction in a mammalian alpha-amylase. High-resolution structural analysis of an enzyme-inhibitor complex
Biochemistry, 40, 2001
5E0F
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BU of 5e0f by Molmil
Human pancreatic alpha-amylase in complex with mini-montbretin A
分子名称: 5,7-dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl 6-deoxy-2-O-{6-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranosyl}-alpha-L-mannopyranoside, CALCIUM ION, CHLORIDE ION, ...
著者Caner, S, Brayer, G.D.
登録日2015-09-28
公開日2016-09-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Human pancreatic alpha-amylase in complex with mini-montbretin A
To Be Published
6Z8L
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BU of 6z8l by Molmil
Alpha-Amylase in complex with probe fragments
分子名称: CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ...
著者Adam, S, Koehnke, J.
登録日2020-06-02
公開日2020-12-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.40000367 Å)
主引用文献Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design.
Chem Sci, 12, 2020
3IJ8
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Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase
分子名称: (2R,3S,4R,5R,6R)-2,6-difluoro-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, 5-fluoro-alpha-L-idopyranose, CALCIUM ION, ...
著者Li, C, Zhang, R, Withers, S.G, Brayer, G.D.
登録日2009-08-04
公開日2009-10-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase
Biochemistry, 48, 2009
3OLI
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BU of 3oli by Molmil
Structures of human pancreatic alpha-amylase in complex with acarviostatin IV03
分子名称: (1S,2S,3R,6R)-6-amino-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ...
著者Qin, X, Ren, L.
登録日2010-08-26
公開日2011-04-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.
J.Struct.Biol., 174, 2011
3DHP
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BU of 3dhp by Molmil
Probing the role of aromatic residues at the secondary saccharide binding sites of human salivary alpha-amylase in substrate hydrolysis and bacterial binding
分子名称: 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, Alpha-amylase 1, ...
著者Ragunath, C, Manuel, S.G.A, Sait, H.M, Kasinathan, C.
登録日2008-06-18
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Probing the role of aromatic residues
To be Published
3OLE
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BU of 3ole by Molmil
Structures of human pancreatic alpha-amylase in complex with acarviostatin II03
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, ...
著者Qin, X, Ren, L.
登録日2010-08-26
公開日2011-04-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.
J.Struct.Biol., 174, 2011
3BLP
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BU of 3blp by Molmil
Role of aromatic residues in human salivary alpha-amylase
分子名称: 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, Alpha-amylase 1, ...
著者Ramasubbu, N.
登録日2007-12-11
公開日2008-11-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-function relationships in human salivary alpha-amylase: role of aromatic residues in a secondary binding site
Biologia, 63, 2008
3BMV
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BU of 3bmv by Molmil
Cyclodextrin glycosyl transferase from Thermoanerobacterium thermosulfurigenes EM1 mutant S77P
分子名称: CALCIUM ION, Cyclomaltodextrin glucanotransferase, GLYCEROL, ...
著者Rozeboom, H.J, van Oosterwijk, N, Dijkstra, B.W.
登録日2007-12-13
公開日2008-05-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution.
Biochem.J., 413, 2008
6M4L
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BU of 6m4l by Molmil
X-ray crystal structure of the E249Q mutant of alpha-amylase I from Eisenia fetida
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
著者Hirano, Y, Tsukamoto, K, Ariki, S, Naka, Y, Ueda, M, Tamada, T.
登録日2020-03-07
公開日2020-09-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献X-ray crystallographic structural studies of alpha-amylase I from Eisenia fetida.
Acta Crystallogr D Struct Biol, 76, 2020
3BMW
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BU of 3bmw by Molmil
Cyclodextrin glycosyl transferase from Thermoanerobacterium thermosulfurigenes EM1 mutant S77P complexed with a maltoheptaose inhibitor
分子名称: 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, CALCIUM ION, CHLORIDE ION, ...
著者Rozeboom, H.J, van Oosterwijk, N, Dijkstra, B.W.
登録日2007-12-13
公開日2008-05-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution.
Biochem.J., 413, 2008
1KXQ
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BU of 1kxq by Molmil
Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase
分子名称: CALCIUM ION, CHLORIDE ION, alpha-amylase, ...
著者Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C.
登録日2002-02-01
公開日2002-06-19
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1Z32
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Structure-function relationships in human salivary alpha-amylase: Role of aromatic residues
分子名称: 4-amino-4,6-dideoxy-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, CALCIUM ION, ...
著者Ramasubbu, N, Ragunath, C, Sundar, K, Mishra, P.J, Gyemant, G, Kandra, L.
登録日2005-03-10
公開日2005-05-31
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-function relationships in human salivary alpha-amylase: Role of aromatic residues
To be Published
1KXV
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Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase
分子名称: ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10
著者Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C.
登録日2002-02-01
公開日2002-06-19
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1SMD
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HUMAN SALIVARY AMYLASE
分子名称: AMYLASE, CALCIUM ION, CHLORIDE ION
著者Ramasubbu, N.
登録日1996-01-24
公開日1996-07-11
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity.
Acta Crystallogr.,Sect.D, 52, 1996
1JAE
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STRUCTURE OF TENEBRIO MOLITOR LARVAL ALPHA-AMYLASE
分子名称: ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION
著者Strobl, S, Maskos, K, Betz, M, Wiegand, G, Huber, R, Gomis-Rueth, F.X, Frank, G, Glockshuber, R.
登録日1997-09-30
公開日1998-11-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of yellow meal worm alpha-amylase at 1.64 A resolution.
J.Mol.Biol., 278, 1998

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