3OLE

Structures of human pancreatic alpha-amylase in complex with acarviostatin II03

Summary for 3OLE

• Entry DOI: 10.2210/pdb3ole/pdb
• Related: 3OLD 3OLG
• Related PRD ID: PRD_900009 PRD_900065
• Descriptor: Pancreatic alpha-amylase, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, PYROGLUTAMIC ACID, ... (13 entities in total)
• Functional Keywords: glycosylation, hydrolase-hydrolase inhibitor complex, acarviostatin ii03, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space: P04746
• Total number of polymer chains: 1
• Total formula weight: 58794.47

Authors

Qin, X.,Ren, L. (deposition date: 2010-08-26, release date: 2011-04-13, Last modification date: 2023-11-01)

• Primary citation: Qin, X.,Ren, L.,Yang, X.,Bai, F.,Wang, L.,Geng, P.,Bai, G.,Shen, Y.; Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.; J.Struct.Biol., 174:196-202, 2011; PubMed: 21111049; DOI: 10.1016/j.jsb.2010.11.020

Experimental method

X-RAY DIFFRACTION (1.55 Å)