3OLE
Structures of human pancreatic alpha-amylase in complex with acarviostatin II03
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Pancreatic alpha-amylase | polymer | 496 | 55980.4 | 1 | UniProt (P04746) Pfam (PF00128) Pfam (PF02806) In PDB | Homo sapiens (human) | PA, 1,4-alpha-D-glucan glucanohydrolase |
2 | B | alpha-D-quinovopyranose-(1-4)-alpha-D-glucopyranose | branched | 326.3 | 1 | In PDB GlyTouCan (G96906VH) | |||
3 | C | alpha-D-quinovopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 488.4 | 1 | In PDB GlyTouCan (G31885RT) | |||
4 | D | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 504.4 | 1 | In PDB BIRD (PRD_900009) GlyTouCan (G96370VA) | alpha-maltotriose | ||
5 | E | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose | branched | 504.4 | 1 | In PDB BIRD (PRD_900065) GlyTouCan (G00395FS) | beta-maltotriose | ||
6 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
7 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
9 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
10 | A | 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL | non-polymer | 175.2 | 2 | Chemie (ACI) | |||
11 | A | PYROGLUTAMIC ACID | non-polymer | 129.1 | 1 | Chemie (PCA) | |||
12 | A | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
13 | water | water | 18.0 | 530 | Chemie (HOH) |
Sequence modifications
A: 1 - 496 (UniProt: P04746)
PDB | External Database | Details |
---|---|---|
Met 287 | Val 302 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 55980.4 | |
Branched | Number of molecules | 4 |
Total formula weight | 1823.6 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 990.5 | |
All* | Total formula weight | 58794.5 |