4GQR
Human Pancreatic alpha-amylase in complex with myricetin
Summary for 4GQR
| Entry DOI | 10.2210/pdb4gqr/pdb |
| Related | 1BSI 1CPU 1HNY 3IJ7 3IJ8 4GQQ |
| Descriptor | Pancreatic alpha-amylase, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (6 entities in total) |
| Functional Keywords | glycosyl hydrolase, diabetes, obesity, digestion, glycosidase, enzyme inhibition, flavonol, drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted, extracellular space: P04746 |
| Total number of polymer chains | 1 |
| Total formula weight | 56546.28 |
| Authors | Williams, L.K.,Brayer, G.D. (deposition date: 2012-08-23, release date: 2012-10-24, Last modification date: 2020-07-29) |
| Primary citation | Williams, L.K.,Li, C.,Withers, S.G.,Brayer, G.D. Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target. J.Med.Chem., 55:10177-10186, 2012 Cited by PubMed: 23050660DOI: 10.1021/jm301273u PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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