7ZYI
| Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | 分子名称: | CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ... | 著者 | Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2022-05-24 | 公開日 | 2022-07-13 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver. Cell Res., 32, 2022
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7FCI
| human NTCP in complex with YN69083 Fab | 分子名称: | Fab Heavy chain, Fab Light chain, Sodium/bile acid cotransporter | 著者 | Park, J.H, Iwamoto, M, Yun, J.H, Uchikubo-Kamo, T, Son, D, Jin, Z, Yoshida, H, Ohki, M, Ishimoto, N, Mizutani, K, Oshima, M, Muramatsu, M, Wakita, T, Shirouzu, M, Liu, K, Uemura, T, Nomura, N, Iwata, S, Watashi, K, Tame, J.R.H, Nishizawa, T, Lee, W, Park, S.Y. | 登録日 | 2021-07-14 | 公開日 | 2022-05-25 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into the HBV receptor and bile acid transporter NTCP. Nature, 606, 2022
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8RQF
| Cryo-EM structure of human NTCP-Bulevirtide complex | 分子名称: | Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ... | 著者 | Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P. | 登録日 | 2024-01-18 | 公開日 | 2024-03-27 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP. Nat Commun, 15, 2024
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3ZUX
| Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. | 分子名称: | LAURYL DIMETHYLAMINE-N-OXIDE, MERCURY (II) ION, PHOSPHATIDYLETHANOLAMINE, ... | 著者 | Hu, N.-J, Iwata, S, Cameron, A.D, Drew, D. | 登録日 | 2011-07-21 | 公開日 | 2011-10-12 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of a Bacterial Homologue of the Bile Acid Sodium Symporter Asbt. Nature, 478, 2011
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3ZUY
| Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. | 分子名称: | LAURYL DIMETHYLAMINE-N-OXIDE, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | 著者 | Hu, N.-J, Iwata, S, Cameron, A.D, Drew, D. | 登録日 | 2011-07-21 | 公開日 | 2011-10-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of a Bacterial Homologue of the Bile Acid Sodium Symporter Asbt. Nature, 478, 2011
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7CYG
| Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter before disulfide bond formation | 分子名称: | Transporter, sodium/bile acid symporter family | 著者 | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | 登録日 | 2020-09-03 | 公開日 | 2021-01-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.198 Å) | 主引用文献 | An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter. Acta Crystallogr D Struct Biol, 77, 2021
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7CYK
| Crystal structure of a second cysteine-pair mutant (V110C-I197C) of a bacterial bile acid transporter before disulfide bond formation | 分子名称: | MERCURY (II) ION, Transporter, sodium/bile acid symporter family | 著者 | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | 登録日 | 2020-09-03 | 公開日 | 2021-01-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.785 Å) | 主引用文献 | An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter. Acta Crystallogr D Struct Biol, 77, 2021
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7PQG
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8HRX
| Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex | 分子名称: | Fab heavy chain from antibody IgG clone number YN9048, Fab light chain from antibody IgG clone number YN9048, PreS1 protein (Fragment), ... | 著者 | Asami, J, Shimizu, T, Ohto, U. | 登録日 | 2022-12-16 | 公開日 | 2024-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural basis of hepatitis B virus receptor binding. Nat.Struct.Mol.Biol., 31, 2024
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8HRY
| Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex | 分子名称: | Fab heavy chain from antibody IgG clone number YN9016, Fab light chain from antibody IgG clone number YN9016, Large S protein (Fragment), ... | 著者 | Asami, J, Shimizu, T, Ohto, U. | 登録日 | 2022-12-16 | 公開日 | 2024-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis of hepatitis B virus receptor binding. Nat.Struct.Mol.Biol., 31, 2024
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8OYF
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8OYG
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6LGY
| Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with glycine and sodium | 分子名称: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLYCINE, NONAETHYLENE GLYCOL, ... | 著者 | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | 登録日 | 2019-12-06 | 公開日 | 2020-12-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.247 Å) | 主引用文献 | Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii. Acta Crystallogr D Struct Biol, 77, 2021
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6LH0
| Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing apo-state | 分子名称: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Transporter, sodium/bile acid symporter family | 著者 | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | 登録日 | 2019-12-06 | 公開日 | 2020-12-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.812 Å) | 主引用文献 | Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii. Acta Crystallogr D Struct Biol, 77, 2021
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6LGZ
| Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with sulfate | 分子名称: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, SULFATE ION, Transporter, ... | 著者 | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | 登録日 | 2019-12-06 | 公開日 | 2020-12-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.428 Å) | 主引用文献 | Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii. Acta Crystallogr D Struct Biol, 77, 2021
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6LH1
| Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter trapped in an outward-facing conformation | 分子名称: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRIC ACID, Transporter, ... | 著者 | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | 登録日 | 2019-12-06 | 公開日 | 2020-12-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.861 Å) | 主引用文献 | An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter. Acta Crystallogr D Struct Biol, 77, 2021
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6LGV
| Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with citrate | 分子名称: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRIC ACID, Transporter, ... | 著者 | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | 登録日 | 2019-12-06 | 公開日 | 2020-12-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.847 Å) | 主引用文献 | Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii. Acta Crystallogr D Struct Biol, 77, 2021
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7VAF
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7VAG
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7VAD
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7VAE
| Cryo-EM structure of bovine NTCP complexed with YN69202Fab | 分子名称: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ... | 著者 | Asami, J, Shimizu, T, Ohto, U. | 登録日 | 2021-08-29 | 公開日 | 2022-05-25 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606, 2022
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7WSI
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7PQQ
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