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8QES
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E coli NfsB with the unnatural amino acid, p-aminoPhe at position 124
分子名称: FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, Oxygen-insensitive NAD(P)H nitroreductase
著者Day, M.A, White, S.A, Hyde, E.I.
登録日2023-09-01
公開日2024-08-14
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献The structure of E coli NfsB nitroreducasr with unnatural amino acids at position 124
To Be Published
8QPO
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BU of 8qpo by Molmil
E. coli NfsB with the unnatural amino acid p-nitrophenylalanine at position 124.
分子名称: ACETATE ION, FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase
著者Day, M.A, White, S.A, Hyde, E.I.
登録日2023-10-02
公開日2024-08-14
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献E. coli NfsB with unnatural amino acids at position 124.
To Be Published
8UC3
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BU of 8uc3 by Molmil
Cryo-EM structure of the AlbAB cyclodipeptide oxidase enzyme filament
分子名称: Albonoursin synthase, FLAVIN MONONUCLEOTIDE, Protein AlbB
著者Andreas, M.P, Giessen, T.W.
登録日2023-09-25
公開日2024-05-15
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (2.78 Å)
主引用文献Cyclodipeptide oxidase is an enzyme filament.
Nat Commun, 15, 2024
8QYG
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BU of 8qyg by Molmil
Crystal structure of Nitroreductase from Bacillus tequilensis
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Rozeboom, H.J, Russo, S, Fraaije, M.W, Poelarends, G.J.
登録日2023-10-26
公開日2024-05-08
最終更新日2024-08-21
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase.
Febs J., 2024
8CQT
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BU of 8cqt by Molmil
Flavin mononucleotide-dependent nitroreductase B.thetaiotaomicron (BT_1316)
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, Putative NADH dehydrogenase/NAD(P)H nitroreductase
著者Blaha, J, Adam, L, Beckham, K.S.H, Chojnowski, G, Wilmanns, M, Zimmermann, M.
登録日2023-03-07
公開日2024-03-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural insights into the diversity of nitroreductase enzymes in Bacteroides thetaiotaomicron
To Be Published
8CQU
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BU of 8cqu by Molmil
Flavin mononucleotide-dependent nitroreductase B.thetaiotaomicron (BT_1680)
分子名称: CITRIC ACID, Putative NADH dehydrogenase/NAD(P)H nitroreductase, TERTIARY-BUTYL ALCOHOL
著者Blaha, J, Adam, L, Beckham, K.S.H, Chojnowski, G, Wilmanns, M, Zimmermann, M.
登録日2023-03-07
公開日2024-03-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into the diversity of nitroreductase enzymes in Bacteroides thetaiotaomicron
To Be Published
8CQV
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BU of 8cqv by Molmil
Flavin mononucleotide-dependent nitroreductase B.thetaiotaomicron (BT_3392)
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, FLAVIN MONONUCLEOTIDE, ...
著者Blaha, J, Adam, L, Beckham, K.S.H, Chojnowski, G, Wilmanns, M, Zimmermann, M.
登録日2023-03-07
公開日2024-03-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural insights into the diversity of nitroreductase enzymes in Bacteroides thetaiotaomicron
To Be Published
8CQS
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BU of 8cqs by Molmil
Flavin mononucleotide-dependent nitroreductase B.thetaiotaomicron (BT_0217)
分子名称: FLAVIN MONONUCLEOTIDE, Nitroreductase-like protein, PHOSPHATE ION
著者Blaha, J, Gratzl, S, Mortensen, S.A, Beckham, K.S.H, Chojnowski, G, Wilmanns, M, Zimmermann, M.
登録日2023-03-07
公開日2024-03-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural insights into the diversity of nitroreductase enzymes in Bacteroides thetaiotaomicron
To Be Published
8Q5G
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BU of 8q5g by Molmil
Crystal structure of nitroreductase from Bacillus tequilensis with covalent FMN
分子名称: FLAVIN MONONUCLEOTIDE, NAD(P)H-dependent oxidoreductase
著者Rozeboom, H.J, Fraaije, M.W.
登録日2023-08-09
公開日2023-11-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Fixing Flavins: Hijacking a Flavin Transferase for Equipping Flavoproteins with a Covalent Flavin Cofactor.
J.Am.Chem.Soc., 145, 2023
8PZ5
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BU of 8pz5 by Molmil
Structure of ThcOx, solved at wavelength 3.099 A
分子名称: FLAVIN MONONUCLEOTIDE, SagB-type dehydrogenase domain protein
著者Duman, R, El Omari, K, Mykhaylyk, V, Orr, C, Wagner, A.
登録日2023-07-27
公開日2023-10-25
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Commun Chem, 6, 2023
7XWW
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BU of 7xww by Molmil
Crystal structure of NTR in complex with BN-XB
分子名称: 2,2-bis(fluoranyl)-4,6,10,12-tetramethyl-8-[1-[(4-nitrophenyl)methyl]pyridin-1-ium-4-yl]-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.0^{3,7}]dodeca-1(12),4,6,8,10-pentaene, Dihydropteridine reductase, FLAVIN MONONUCLEOTIDE
著者Chen, X, Chen, J, Li, J.L.
登録日2022-05-27
公開日2023-05-31
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of NTR in complex with BN-XB
To Be Published
8C5P
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BU of 8c5p by Molmil
E. coli NfsB mutant N71S T41L with acetate
分子名称: 1,2-ETHANEDIOL, ACETATE ION, DIMETHYL SULFOXIDE, ...
著者Day, M.A, White, S.A, Hyde, E.I.
登録日2023-01-10
公開日2023-04-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8CCV
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BU of 8ccv by Molmil
E. coli NfsB mutant T41LN71S with nicotinate
分子名称: FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, Oxygen-insensitive NAD(P)H nitroreductase
著者Day, M.A, White, S.A, Hyde, E.I, Searle, P.F.
登録日2023-01-27
公開日2023-04-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8CJ0
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BU of 8cj0 by Molmil
E. coli NfsB-T41Q/N71S/F124T/M127V mutant bound to nicotinate
分子名称: 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, ...
著者White, S.A, Hyde, E.I, Day, M.A.
登録日2023-02-11
公開日2023-04-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8C5E
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BU of 8c5e by Molmil
E. coli NfsB-T41Q/N71S/F124T mutant bound to nicotinic acid
分子名称: 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, ...
著者White, S.A, Hyde, E.I, Day, M.A.
登録日2023-01-06
公開日2023-04-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8C5F
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BU of 8c5f by Molmil
E. coli NfsB-T41Q/N71S/F124T mutant bound to acetate
分子名称: 1,2-ETHANEDIOL, ACETATE ION, FLAVIN MONONUCLEOTIDE, ...
著者White, S.A, Hyde, E.I, Day, M.A.
登録日2023-01-07
公開日2023-04-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8OG3
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BU of 8og3 by Molmil
E. coli NfsB triple mutant T41L/N71S/F124T bound to citrate
分子名称: 1,2-ETHANEDIOL, CITRIC ACID, FLAVIN MONONUCLEOTIDE, ...
著者Day, M.A, White, S.A, Hyde, E.I, Searle, P.F.
登録日2023-03-17
公開日2023-04-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8AJX
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BU of 8ajx by Molmil
E. coli NfsA with Fumarate
分子名称: 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, FUMARIC ACID, ...
著者Day, M.A, Jarrom, D, White, S.A, Hyde, E.I.
登録日2022-07-28
公開日2023-01-18
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Oxygen-insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate.
Proteins, 91, 2023
7VQK
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BU of 7vqk by Molmil
Catalytic manifolds of a FMN-dependent oxidoreductase RubE7, expanding the functional diversity of the flavoenzyme superfamily
分子名称: FLAVIN MONONUCLEOTIDE, FMN-dependent oxidoreductase IstO
著者Yan, Y.J, Huang, S.X.
登録日2021-10-20
公開日2022-10-26
最終更新日2023-06-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Characterization of Multifunctional and Non-stereoselective Oxidoreductase RubE7/IstO, Expanding the Functional Diversity of the Flavoenzyme Superfamily.
Angew.Chem.Int.Ed.Engl., 61, 2022
7X32
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Crystal structure of E. coli NfsB in complex with berberine
分子名称: BERBERINE, DIMETHYL SULFOXIDE, Dihydropteridine reductase, ...
著者Zhang, H, Wen, H.Y.
登録日2022-02-27
公開日2022-10-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.829 Å)
主引用文献Structural basis for the transformation of the traditional medicine berberine by bacterial nitroreductase.
Acta Crystallogr D Struct Biol, 78, 2022
8DOR
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BU of 8dor by Molmil
Crystal structure of Dihydropteridine reductase/oxygen-insensitive NAD(P)H nitroreductase from Klebsiella pneumoniae
分子名称: Dihydropteridine reductase/oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-07-14
公開日2022-07-27
最終更新日2024-08-21
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae.
Acta Crystallogr.,Sect.F, 80, 2024
7Z0W
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E. coli NfsA bound to NADP+
分子名称: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, FLAVIN MONONUCLEOTIDE, MAGNESIUM ION, ...
著者White, S.A, Grainger, A, Parr, R, Day, M.A, Jarrom, D, Graziano, A, Searle, P.F, Hyde, E.I.
登録日2022-02-23
公開日2022-07-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献The 3D-structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP + provide glimpses of its catalytic mechanism.
Febs Lett., 596, 2022
8DIL
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BU of 8dil by Molmil
Crystal structure of putative nitroreductase from Salmonella enterica
分子名称: 1,2-ETHANEDIOL, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ...
著者Chang, C, Skarina, T, Mesa, N, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2022-06-29
公開日2022-07-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of putative nitroreductase from Salmonella enterica
to be published
7Q0O
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E. coli NfsA
分子名称: FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NADPH nitroreductase
著者White, S.A, Grainger, A, Parr, R, Day, M.A, Jarrom, D, Graziano, A, Searle, P.F, Hyde, E.I.
登録日2021-10-15
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (0.96 Å)
主引用文献The 3D-structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP + provide glimpses of its catalytic mechanism.
Febs Lett., 596, 2022
7UWT
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Structure of Oxygen-Insensitive NAD(P)H-dependent Nitroreductase NfsB_Vv F70A/F108Y (NTR 2.0) in complex with FMN at 1.85 Angstroms resolution
分子名称: ACETATE ION, Dihydropteridine reductase, FLAVIN MONONUCLEOTIDE, ...
著者Sharrock, A.V, Arcus, V, Mumm, J.S, Ackerley, D.F.
登録日2022-05-03
公開日2022-05-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity.
Int J Mol Sci, 24, 2023

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件を2024-10-16に公開中

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