7UWT

Structure of Oxygen-Insensitive NAD(P)H-dependent Nitroreductase NfsB_Vv F70A/F108Y (NTR 2.0) in complex with FMN at 1.85 Angstroms resolution

Summary for 7UWT

• Entry DOI: 10.2210/pdb7uwt/pdb
• Descriptor: Dihydropteridine reductase, FLAVIN MONONUCLEOTIDE, ACETATE ION, ... (5 entities in total)
• Functional Keywords: nitroreductase, oxidoreductase, flavoenzyme, metronidazole reductase
• Biological source: Vibrio vulnificus
• Total number of polymer chains: 2
• Total formula weight: 51317.88

Authors

Sharrock, A.V.,Arcus, V.,Mumm, J.S.,Ackerley, D.F. (deposition date: 2022-05-03, release date: 2022-05-18, Last modification date: 2023-10-25)

• Primary citation: Sharrock, A.V.,Mumm, J.S.,Bagdziunas, G.,Cenas, N.,Arcus, V.L.,Ackerley, D.F.; The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity.; Int J Mol Sci, 24:-, 2023; PubMed: 37047605; DOI: 10.3390/ijms24076633

Experimental method

X-RAY DIFFRACTION (1.85 Å)