1FSH
 
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1O7F
 | | CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2 | | 分子名称: | CAMP-DEPENDENT RAP1 GUANINE-NUCLEOTIDE EXCHANGE FACTOR | | 著者 | Rehmann, H, Prakash, B, Wolf, E, Rueppel, A, De Rooij, J, Bos, J.L, Wittinghofer, A. | | 登録日 | 2002-11-04 | | 公開日 | 2002-11-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure and Regulation of the Camp-Binding Domains of Epac2
Nat.Struct.Biol., 10, 2002
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1UHW
 | | Solution structure of the DEP domain of mouse pleckstrin | | 分子名称: | Pleckstrin | | 著者 | Inoue, K, Yoshida, M, Hatta, R, Hayashi, F, Shirouzu, M, Terada, T, Kigawa, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Tanaka, A, Osanai, T, Matsuo, Y, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-07-11 | | 公開日 | 2004-01-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the DEP domain of mouse pleckstrin
To be Published
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1V3F
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1W4M
 | | Structure of the human pleckstrin DEP domain by multidimensional NMR | | 分子名称: | PLECKSTRIN | | 著者 | Civera, C, Simon, B, Stier, G, Sattler, M, Macias, M.J. | | 登録日 | 2004-07-26 | | 公開日 | 2004-12-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Dynamics of the Human Pleckstrin Dep Domain: Distinct Molecular Features of a Novel Dep Domain Subfamily
Proteins: Struct.,Funct., Genet., 58, 2005
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2BYV
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2CSO
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2PBI
 | | The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure | | 分子名称: | GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9 | | 著者 | Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J. | | 登録日 | 2007-03-28 | | 公開日 | 2008-01-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
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2YSR
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3ML6
 | | a complex between Dishevelled2 and clathrin adaptor AP-2 | | 分子名称: | Chimeric complex between protein Dishevelled2 homolog dvl-2 and clathrin adaptor AP-2 complex subunit mu | | 著者 | Yu, A, Xing, Y, Harrison, S.C, Kirchhausen, T.L. | | 登録日 | 2010-04-16 | | 公開日 | 2010-08-11 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.
Structure, 18, 2010
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4F7Z
 | | Conformational dynamics of exchange protein directly activated by cAMP | | 分子名称: | GLYCEROL, Rap guanine nucleotide exchange factor 4 | | 著者 | White, M.A, Tsalkova, T.N, Mei, F.C, Liu, T, Woods, V.L, Cheng, X. | | 登録日 | 2012-05-16 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.
Plos One, 7, 2012
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5LNP
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5SUY
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5SUZ
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6CES
 | | Cryo-EM structure of GATOR1-RAG | | 分子名称: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | | 著者 | Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. | | 登録日 | 2018-02-12 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Nature, 556, 2018
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6CET
 | | Cryo-EM structure of GATOR1 | | 分子名称: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3 | | 著者 | Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. | | 登録日 | 2018-02-12 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Nature, 556, 2018
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6H7E
 | | GEF regulatory domain | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ... | | 著者 | Ferrandez, Y, Cherfils, J, Peurois, F. | | 登録日 | 2018-07-31 | | 公開日 | 2020-02-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Nat Commun, 14, 2023
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6N9G
 | | Crystal Structure of RGS7-Gbeta5 dimer | | 分子名称: | Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7 | | 著者 | Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A. | | 登録日 | 2018-12-03 | | 公開日 | 2019-01-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.129 Å) | | 主引用文献 | Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex.
Elife, 7, 2018
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6PCV
 | | Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 | | 著者 | Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. | | 登録日 | 2019-06-18 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
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6VSK
 | | Crystal structure of the P-Rex1 DEP1 domain | | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | | 著者 | Tesmer, J, Ravala, S.K. | | 登録日 | 2020-02-11 | | 公開日 | 2020-07-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.
J.Biol.Chem., 295, 2020
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7DKL
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7EWP
 | | Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio | | 分子名称: | Guanine nucleotide-binding protein subunit beta-5, Probable G-protein coupled receptor 158, Regulator of G-protein signaling 7 | | 著者 | Kim, Y, Jeong, E, Jeong, J, Cho, Y. | | 登録日 | 2021-05-25 | | 公開日 | 2021-12-01 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure of the class C orphan GPCR GPR158 in complex with RGS7-G beta 5.
Nat Commun, 12, 2021
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7EWR
 | | Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio | | 分子名称: | Guanine nucleotide-binding protein subunit beta-5, Probable G-protein coupled receptor 158, Regulator of G-protein signaling 7 | | 著者 | Kim, Y, Jeong, E, Jeong, J, Cho, Y. | | 登録日 | 2021-05-26 | | 公開日 | 2021-12-01 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Structure of the class C orphan GPCR GPR158 in complex with RGS7-G beta 5.
Nat Commun, 12, 2021
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7OWG
 | | human DEPTOR in a complex with mutant human mTORC1 A1459P | | 分子名称: | DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... | | 著者 | Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. | | 登録日 | 2021-06-18 | | 公開日 | 2021-09-08 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Elife, 10, 2021
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7PE7
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