PDB: 621 件ウェブページステータス検索Chemie searchBIRD

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9AXA	CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628 分子名称: 14-3-3 protein sigma, Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, ... 著者 Quade, B, Cohen, S.E, Huang, X. 登録日 2024-03-06 公開日 2024-04-17 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (4.36 Å) 主引用文献 The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
8XI3	Structure of mouse SCMC-14-3-3gama complex 分子名称: 14-3-3 protein gamma, NACHT, LRR and PYD domains-containing protein 5, ... 著者 Chi, P, Han, Z, Jiao, H, Li, J, Wang, X, Hu, H, Deng, D. 登録日 2023-12-19 公開日 2024-10-02 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of mouse SCMC-14-3-3gama complex To Be Published
8R0Z	14-3-3 sigma in complex with TAZ peptide and stabilizing fragment TCF199 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, WW domain-containing transcription regulator protein 1, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2023-11-01 公開日 2024-09-04 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction. Biochemistry, 63, 2024
8QTT	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1. 分子名称: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-13 公開日 2023-11-15 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-10-25 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-11-15 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTF	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-11-22 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8WF6	14-3-3 zeta complexed with S559 phosphorylated peptide derived from GPIb alpha cytoplasmic domain 分子名称: 14-3-3 protein zeta/delta, S559 phosphorylated peptide, SUCCINIC ACID 著者 Shu, Z.M, Zhou, A.W. 登録日 2023-09-19 公開日 2024-09-25 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Cryo-EM structure of GPIb-IX Complex To Be Published
8WE2	14-3-3 zeta complexed with S609 phosphorylated peptide derived from GPIb alpha cytoplasmic domain 分子名称: 14-3-3 protein zeta/delta, S609 phosphorylated peptide 著者 Shu, Z.M, Zhou, A.W. 登録日 2023-09-16 公開日 2024-09-25 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structure of 14-3-3 zeta complexed with phosphorylated peptides derived from GPIb alpha cytoplasmic domain To Be Published
8QDV	Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide 分子名称: 14-3-3 protein zeta/delta, Microtubule-associated protein tau 著者 van den Oetelaar, M.C.M, Brunsveld, L, Ottmann, C. 登録日 2023-08-30 公開日 2024-09-11 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 14-3-3zeta binding increases cytosolic phospho-Tau solubility by decreasing its condensation, aggregation, and microtubule association To Be Published
8Q4L	GBP1 bound by 14-3-3sigma 分子名称: 14-3-3 protein sigma, Guanylate-binding protein 1 著者 Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P. 登録日 2023-08-07 公開日 2023-10-11 最終更新日 2023-10-18 実験手法 ELECTRON MICROSCOPY (5.12 Å) 主引用文献 PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science, 382, 2023
8Q1S	Pathogenic mutations of human phosphorylation sites affect protein-protein interactions 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... 著者 Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. 登録日 2023-08-01 公開日 2024-02-21 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 Pathogenic mutations of human phosphorylation sites affect protein-protein interactions. Nat Commun, 15, 2024
8P1H	Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor 分子名称: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ... 著者 Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N. 登録日 2023-05-12 公開日 2023-10-18 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. Biochem.Biophys.Res.Commun., 682, 2023
8P0D	Human 14-3-3 sigma in complex with human MDM2 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. 登録日 2023-05-10 公開日 2024-02-21 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
8CPD	Cryo-EM structure of CRaf dimer with 14:3:3 分子名称: 14-3-3 protein zeta isoform X1, RAF proto-oncogene serine/threonine-protein kinase 著者 Dedden, D, Graedler, U, Schwarz, D, Thomsen, M, Leuthner, B, Schneider, E, Nitsche, J. 登録日 2023-03-02 公開日 2024-02-21 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.46 Å) 主引用文献 Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
8CHF	cryo-EM Structure of Craf:14-3-3:Mek1 分子名称: 14-3-3 protein zeta isoform X1, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Dedden, D, Ulrich, G. 登録日 2023-02-07 公開日 2024-02-21 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (4.25 Å) 主引用文献 Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
8BYO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2023-01-18 公開日 2023-08-02 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4G	Small molecule amidine soak in 14-3-3/ERa (AZ132) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2023-01-03 公開日 2023-08-02 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F	Small molecule amidine soak in 14-3-3/ERa (AZ037) 分子名称: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2023-01-03 公開日 2023-08-02 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C40	14-3-3sigma bound to PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen Receptor alpha phosphopeptide, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C43	Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. 分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C42	Ternary structure of 14-3-3sigma, PKA-responsive ERa phosphopeptide and Fusicoccin-A 分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen receptor, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C3Z	14-3-3sigma bound to strep-tagged PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C2Y	14-3-3 in complex with Pyrinp pS242 分子名称: 14-3-3 protein sigma, Pyrin pS242 peptide 著者 Lau, R, Ottmann, C, Hann, M. 登録日 2022-12-23 公開日 2024-01-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 14-3-3/Pyrin complex To Be Published
8C30	Crystal structure of 14-3-3 in complex with PyrinpS242 and a protein/peptide interface fragment 分子名称: 14-3-3 protein sigma, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CALCIUM ION, ... 著者 Lau, R, Ottmann, C. 登録日 2022-12-23 公開日 2024-01-10 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 14-3-3/Pyrin complex To Be Published

 

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