9AXA
CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628
This is a non-PDB format compatible entry.
Summary for 9AXA
Entry DOI | 10.2210/pdb9axa/pdb |
EMDB information | 43931 |
Descriptor | GST26/CRAF chimera, Dual specificity mitogen-activated protein kinase kinase 1, 14-3-3 protein sigma, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, signaling protein, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 273225.96 |
Authors | Quade, B.,Cohen, S.E.,Huang, X. (deposition date: 2024-03-06, release date: 2024-04-17, Last modification date: 2024-07-10) |
Primary citation | Ryan, M.B.,Quade, B.,Schenk, N.,Fang, Z.,Zingg, M.,Cohen, S.E.,Swalm, B.M.,Li, C.,Ozen, A.,Ye, C.,Ritorto, M.S.,Huang, X.,Dar, A.C.,Han, Y.,Hoeflich, K.P.,Hale, M.,Hagel, M. The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14:1190-1205, 2024 Cited by PubMed: 38588399DOI: 10.1158/2159-8290.CD-24-0139 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.36 Å) |
Structure validation
Download full validation report