8QDV
Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide
Summary for 8QDV
Entry DOI | 10.2210/pdb8qdv/pdb |
Descriptor | 14-3-3 protein zeta/delta, Microtubule-associated protein tau (3 entities in total) |
Functional Keywords | 14-3-3 zeta, tau, protein-protein interaction, protein binding |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 112776.83 |
Authors | van den Oetelaar, M.C.M.,Brunsveld, L.,Ottmann, C. (deposition date: 2023-08-30, release date: 2024-09-11, Last modification date: 2024-09-18) |
Primary citation | Hochmair, J.,van den Oetelaar, M.C.M.,Ravatt, R.,Lemmens, L.J.M.,Ponce, R.,Semenova, E.,Mohapatra, S.,Ottmann, C.,Diez, L.,Brunsveld, L.,Wegmann, S. 14-3-3zeta binding increases cytosolic phospho-Tau solubility by decreasing its condensation, aggregation, and microtubule association To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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