8QDV

Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001525	biological_process	angiogenesis
A	0003016	biological_process	respiratory system process
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0008039	biological_process	synaptic target recognition
A	0008104	biological_process	intracellular protein localization
A	0019901	molecular_function	protein kinase binding
A	0019903	molecular_function	protein phosphatase binding
A	0019904	molecular_function	protein domain specific binding
A	0030324	biological_process	lung development
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031647	biological_process	regulation of protein stability
A	0031982	cellular_component	vesicle
A	0035148	biological_process	tube formation
A	0042149	biological_process	cellular response to glucose starvation
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0044325	molecular_function	transmembrane transporter binding
A	0045296	molecular_function	cadherin binding
A	0045824	biological_process	negative regulation of innate immune response
A	0050815	molecular_function	phosphoserine residue binding
A	0051683	biological_process	establishment of Golgi localization
A	0070062	cellular_component	extracellular exosome
A	0070372	biological_process	regulation of ERK1 and ERK2 cascade
A	0072562	cellular_component	blood microparticle
A	0090128	biological_process	regulation of synapse maturation
A	0090168	biological_process	Golgi reassembly
A	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
A	0098978	cellular_component	glutamatergic synapse
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140311	molecular_function	protein sequestering activity
A	1900181	biological_process	negative regulation of protein localization to nucleus
A	1904262	biological_process	negative regulation of TORC1 signaling
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0001525	biological_process	angiogenesis
B	0003016	biological_process	respiratory system process
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006468	biological_process	protein phosphorylation
B	0007165	biological_process	signal transduction
B	0008039	biological_process	synaptic target recognition
B	0008104	biological_process	intracellular protein localization
B	0019901	molecular_function	protein kinase binding
B	0019903	molecular_function	protein phosphatase binding
B	0019904	molecular_function	protein domain specific binding
B	0030324	biological_process	lung development
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031647	biological_process	regulation of protein stability
B	0031982	cellular_component	vesicle
B	0035148	biological_process	tube formation
B	0042149	biological_process	cellular response to glucose starvation
B	0042470	cellular_component	melanosome
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0044325	molecular_function	transmembrane transporter binding
B	0045296	molecular_function	cadherin binding
B	0045824	biological_process	negative regulation of innate immune response
B	0050815	molecular_function	phosphoserine residue binding
B	0051683	biological_process	establishment of Golgi localization
B	0070062	cellular_component	extracellular exosome
B	0070372	biological_process	regulation of ERK1 and ERK2 cascade
B	0072562	cellular_component	blood microparticle
B	0090128	biological_process	regulation of synapse maturation
B	0090168	biological_process	Golgi reassembly
B	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
B	0098978	cellular_component	glutamatergic synapse
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140311	molecular_function	protein sequestering activity
B	1900181	biological_process	negative regulation of protein localization to nucleus
B	1904262	biological_process	negative regulation of TORC1 signaling
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0001525	biological_process	angiogenesis
E	0003016	biological_process	respiratory system process
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005925	cellular_component	focal adhesion
E	0006468	biological_process	protein phosphorylation
E	0007165	biological_process	signal transduction
E	0008039	biological_process	synaptic target recognition
E	0008104	biological_process	intracellular protein localization
E	0019901	molecular_function	protein kinase binding
E	0019903	molecular_function	protein phosphatase binding
E	0019904	molecular_function	protein domain specific binding
E	0030324	biological_process	lung development
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0031647	biological_process	regulation of protein stability
E	0031982	cellular_component	vesicle
E	0035148	biological_process	tube formation
E	0042149	biological_process	cellular response to glucose starvation
E	0042470	cellular_component	melanosome
E	0042802	molecular_function	identical protein binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0044325	molecular_function	transmembrane transporter binding
E	0045296	molecular_function	cadherin binding
E	0045824	biological_process	negative regulation of innate immune response
E	0050815	molecular_function	phosphoserine residue binding
E	0051683	biological_process	establishment of Golgi localization
E	0070062	cellular_component	extracellular exosome
E	0070372	biological_process	regulation of ERK1 and ERK2 cascade
E	0072562	cellular_component	blood microparticle
E	0090128	biological_process	regulation of synapse maturation
E	0090168	biological_process	Golgi reassembly
E	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
E	0098978	cellular_component	glutamatergic synapse
E	0140297	molecular_function	DNA-binding transcription factor binding
E	0140311	molecular_function	protein sequestering activity
E	1900181	biological_process	negative regulation of protein localization to nucleus
E	1904262	biological_process	negative regulation of TORC1 signaling
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0001525	biological_process	angiogenesis
G	0003016	biological_process	respiratory system process
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005925	cellular_component	focal adhesion
G	0006468	biological_process	protein phosphorylation
G	0007165	biological_process	signal transduction
G	0008039	biological_process	synaptic target recognition
G	0008104	biological_process	intracellular protein localization
G	0019901	molecular_function	protein kinase binding
G	0019903	molecular_function	protein phosphatase binding
G	0019904	molecular_function	protein domain specific binding
G	0030324	biological_process	lung development
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0031647	biological_process	regulation of protein stability
G	0031982	cellular_component	vesicle
G	0035148	biological_process	tube formation
G	0042149	biological_process	cellular response to glucose starvation
G	0042470	cellular_component	melanosome
G	0042802	molecular_function	identical protein binding
G	0043066	biological_process	negative regulation of apoptotic process
G	0044325	molecular_function	transmembrane transporter binding
G	0045296	molecular_function	cadherin binding
G	0045824	biological_process	negative regulation of innate immune response
G	0050815	molecular_function	phosphoserine residue binding
G	0051683	biological_process	establishment of Golgi localization
G	0070062	cellular_component	extracellular exosome
G	0070372	biological_process	regulation of ERK1 and ERK2 cascade
G	0072562	cellular_component	blood microparticle
G	0090128	biological_process	regulation of synapse maturation
G	0090168	biological_process	Golgi reassembly
G	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
G	0098978	cellular_component	glutamatergic synapse
G	0140297	molecular_function	DNA-binding transcription factor binding
G	0140311	molecular_function	protein sequestering activity
G	1900181	biological_process	negative regulation of protein localization to nucleus
G	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

---

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR211-SER230

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Site: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"source":"UniProtKB","id":"P63103","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Potts A.","Barblan J.","Claeys D.","Quadroni M."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA and PKB/AKT1","evidences":[{"source":"PubMed","id":"11956222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12865427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15883165","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16376338","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by MAPK8","evidences":[{"source":"PubMed","id":"15071501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15696159","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P63102","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---