5WXN
 
 | | Structure of the LKB1 and 14-3-3 complex | | 分子名称: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase STK11 | | 著者 | Ding, S, Shi, Z.B. | | 登録日 | 2017-01-08 | | 公開日 | 2017-04-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | | 主引用文献 | Structure of the complex of phosphorylated liver kinase B1 and 14-3-3 zeta
Acta Crystallogr F Struct Biol Commun, 73, 2017
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8HEW
 | | Potato 14-3-3 St14f | | 分子名称: | 14-3-3 protein, StFDL1 peptide | | 著者 | Taoka, K, Kawahara, I, Shinya, S, Harada, K, Muranaka, T, Furuita, K, Nakagawa, A, Fujiwara, T, Tsuji, H, Kojima, C. | | 登録日 | 2022-11-08 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening.
Plant J., 112, 2022
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7O07
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3UBW
 | | Complex of 14-3-3 isoform epsilon, a Mlf1 phosphopeptide and a small fragment hit from a FBDD screen | | 分子名称: | (3S)-pyrrolidin-3-ol, 14-3-3 protein epsilon, Myeloid leukemia factor 1, ... | | 著者 | Molzan, M, Weyand, M, Rose, R, Ottmann, C. | | 登録日 | 2011-10-25 | | 公開日 | 2012-01-25 | | 最終更新日 | 2012-02-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural insights of the MLF1/14-3-3 interaction.
Febs J., 279, 2012
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6EF5
 | | 14-3-3 with peptide | | 分子名称: | 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN | | 著者 | Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W. | | 登録日 | 2018-08-16 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | 14-3-3 with peptide
To Be Published
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4WRQ
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6W0L
 | | Henipavirus W protein interacts with 14-3-3 to modulate host gene expression | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, Phosphorylated W peptide | | 著者 | Edwards, M, Hoad, M, Tsimbalyuk, S, Menicucci, A, Messaoudi, I, Forwood, J, Basler, C. | | 登録日 | 2020-03-01 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Henipavirus W Proteins Interact with 14-3-3 To Modulate Host Gene Expression.
J.Virol., 94, 2020
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6KZH
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5OM0
 | | CH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640 | | 分子名称: | 14-3-3 protein sigma,Zinc finger protein GLI1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION | | 著者 | Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. | | 登録日 | 2017-07-28 | | 公開日 | 2017-10-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners.
Sci Rep, 7, 2017
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5J31
 | | Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS | | 分子名称: | 14-3-3 protein zeta/delta, BENZOIC ACID, Exoenzyme S | | 著者 | Wallraven, K, Cromm, P, Bier, D, Glas, A, Grossmann, T. | | 登録日 | 2016-03-30 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis.
Chembiochem, 17, 2016
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5JM4
 | | Crystal structure of 14-3-3zeta in complex with a cyclic peptide involving an adamantyl and a dicarboxy side chain | | 分子名称: | 14-3-3 protein zeta/delta, BENZOIC ACID, GLN-GLY-MKD-ANG-ASP-MKD-LEU-ASP-LEU-ALA-CLU | | 著者 | Bier, D, Krueger, D, Glas, A, Wallraven, K, Ottmann, C, Hennig, S, Grossmann, T. | | 登録日 | 2016-04-28 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.
J. Med. Chem., 60, 2017
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7V9B
 | | Crystal Structure of 14-3-3 epsilon with FOXO3a peptide | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ARG-ARG-ARG-ALA-VAL-SEP-MET-ASP-ASN-SER-ASN, ... | | 著者 | Mathivanan, S, Kamariah, N. | | 登録日 | 2021-08-24 | | 公開日 | 2022-08-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure of a 14-3-3 epsilon :FOXO3a pS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins.
Acs Omega, 7, 2022
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6XY5
 | | Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 5 | | 分子名称: | 14-3-3 protein sigma, 3-bromanyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... | | 著者 | Somsen, B.A, Ottmann, C. | | 登録日 | 2020-01-29 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers.
Acs Chem.Biol., 15, 2020
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4Y3B
 | | Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma | | 分子名称: | (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C | | 著者 | Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. | | 登録日 | 2015-02-10 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
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5OMA
 | | CH3 chimera of human 14-3-3 sigma with the StARD1 peptide including Ser57 | | 分子名称: | 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. | | 登録日 | 2017-07-28 | | 公開日 | 2017-10-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners.
Sci Rep, 7, 2017
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6KZG
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7XBQ
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4Y32
 | | Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma | | 分子名称: | (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC | | 著者 | Bartel, M, Milroy, L, Bier, D, Brunsveld, L, Ottmann, C. | | 登録日 | 2015-02-10 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
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1YWT
 | | Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1) | | 著者 | Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B. | | 登録日 | 2005-02-18 | | 公開日 | 2005-03-01 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A structural basis for 14-3-3sigma functional specificity.
J.Biol.Chem., 280, 2005
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5IQP
 | | 14-3-3 PROTEIN TAU ISOFORM | | 分子名称: | 14-3-3 protein theta, SULFATE ION | | 著者 | Xiao, B, Smerdon, S.J, Gamblin, S.J. | | 登録日 | 2016-03-11 | | 公開日 | 2016-03-23 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
Nature, 376, 1995
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2WH0
 | | Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon | | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, CALCIUM ION, PROTEIN KINASE C EPSILON TYPE, ... | | 著者 | Kostelecky, B, Saurin, A.T, Purkiss, A, Parker, P.J, McDonald, N.Q. | | 登録日 | 2009-04-28 | | 公開日 | 2009-08-18 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Recognition of an Intra-Chain Tandem 14-3-3 Binding Site within Pkc Epsilon.
Embo Rep., 10, 2009
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6NV2
 | | 14-3-3 sigma with RelA/p65 binding site pS45 in complex with DP005 | | 分子名称: | (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, CHLORIDE ION, ... | | 著者 | Wolter, M, Ottmann, C. | | 登録日 | 2019-02-04 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
J.Am.Chem.Soc., 142, 2020
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1YZ5
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3UX0
 | | Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer Fusicoccin H | | 分子名称: | (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(hydroxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-gulopyranoside, 14-3-3 protein sigma, CHLORIDE ION, ... | | 著者 | Thiel, P, Bartel, M, Anders, C, Higuchi, Y, Schumacher, B, Kato, N, Ottmann, C. | | 登録日 | 2011-12-03 | | 公開日 | 2013-01-02 | | 最終更新日 | 2013-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface.
Chem.Biol., 20, 2013
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3UZD
 | | Crystal structure of 14-3-3 GAMMA | | 分子名称: | 14-3-3 protein gamma, Histone deacetylase 4, MAGNESIUM ION, ... | | 著者 | Xu, C, Bian, C, MacKenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2011-12-07 | | 公開日 | 2012-03-21 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock.
Sci.Signal., 5, 2012
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