PDB: 377 件ウェブページステータス検索Chemie searchBIRD

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6TVE	Unliganded human CD73 (5'-nucleotidase) in the open state 分子名称: 5'-nucleotidase, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Scaletti, E, Strater, N. 登録日 2020-01-09 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem., 63, 2020
6ZEG	Structure of PP1-IRSp53 chimera [PP1(7-304) + linker (G/S)x9 + IRSp53(449-465)] bound to Phactr1 (516-580) 分子名称: 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE, MANGANESE (II) ION, ... 著者 Mouilleron, S, Treisman, R, Fedoryshchak, R, Lee, R, Butler, A.M, Prechova, M. 登録日 2020-06-16 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.09 Å) 主引用文献 Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme. Elife, 9, 2020
2Z72	New Structure Of Cold-Active Protein Tyrosine Phosphatase At 1.1 Angstrom 分子名称: Protein-tyrosine-phosphatase, ZINC ION 著者 Tsuruta, H, Mikami, B, Yamamoto, C, Yamagata, H. 登録日 2007-08-10 公開日 2008-07-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 The role of group bulkiness in the catalytic activity of psychrophile cold-active protein tyrosine phosphatase Febs J., 275, 2008
7PBY	Crystal structure of CD73 in complex with 4-nitrocatechol in the open form 分子名称: 4-NITROCATECHOL, 5'-nucleotidase, CALCIUM ION, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-02 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
5KAR	Murine acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3b, ... 著者 Gorelik, A, Illes, K, Heinz, L.X, Superti-Furga, G, Nagar, B. 登録日 2016-06-02 公開日 2016-10-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.142 Å) 主引用文献 Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity. J.Biol.Chem., 291, 2016
5UQ6	PIG PURPLE ACID PHOSPHATASE COMPLEXED WITH PHOSPHATE IN TWO COORDINATION MODES ALONG WITH A BRIDGING HYDROXIDE ION 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, HYDROXIDE ION, ... 著者 Selleck, C, Guddat, L, Schenk, G, Clayton, D. 登録日 2017-02-06 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.182 Å) 主引用文献 Visualization of the Reaction Trajectory and Transition State in a Hydrolytic Reaction Catalyzed by a Metalloenzyme. Chemistry, 23, 2017
4ZX2	Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 分子名称: (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... 著者 Chattopadhyay, D, Swingle, M.R, Salter, E.A, Wierzbicki, A, Honkanen, R.E. 登録日 2015-05-19 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem. Pharmacol., 109, 2016
3GVE	Crystal structure of calcineurin-like phosphoesterase YfkN from Bacillus subtilis 分子名称: CITRIC ACID, MAGNESIUM ION, MANGANESE (II) ION, ... 著者 Kim, Y, Marshall, N, Cobb, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-03-30 公開日 2009-04-28 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Crystal Structure of Calcineurin-like Phosphoesterase from Bacillus subtilis To be Published
3RL5	Rat metallophosphodiesterase MPPED2 H67R Mutant 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Metallophosphoesterase MPPED2, ... 著者 Podobnik, M, Dermol, U. 登録日 2011-04-19 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. J.Mol.Biol., 412, 2011
7PB5	Crystal structure of CD73 in complex with UMP in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, GLYCEROL, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-07-30 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
3RL4	Rat metallophosphodiesterase MPPED2 G252H Mutant 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Podobnik, M, Dermol, U. 登録日 2011-04-19 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. J.Mol.Biol., 412, 2011
3H63	Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form) 分子名称: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 著者 Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. 登録日 2009-04-23 公開日 2009-09-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52, 2009
3ZTV	Structure of Haemophilus influenzae NAD nucleotidase (NadN) 分子名称: ADENOSINE, GLYCEROL, NAD NUCLEOTIDASE, ... 著者 Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M. 登録日 2011-07-12 公開日 2011-12-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism. Biochem.J., 441, 2012
6ZEH	Structure of PP1-spectrin alpha II chimera [PP1(7-304) + linker (G/S)x9 + spectrin alpha II (1025-1039)] bound to Phactr1 (516-580) 分子名称: MANGANESE (II) ION, PHOSPHATE ION, Phosphatase and actin regulator, ... 著者 Mouilleron, S, Treisman, R, Fedoryshchak, R, Lee, R, Butler, A.M, Prechova, M. 登録日 2020-06-16 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme. Elife, 9, 2020
5INB	RepoMan-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex 分子名称: Cell division cycle-associated protein 2, GLYCEROL, MALONATE ION, ... 著者 Kumar, G.S, Peti, W, Page, R. 登録日 2016-03-07 公開日 2016-10-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. Elife, 5, 2016
8QJZ	Crystal structure of E. coli LpxH in complex with lipid X 分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase 著者 Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. 登録日 2023-09-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024
7PCP	Crystal structure of CD73 in complex with 5-iodouracil in the open form 分子名称: 5'-nucleotidase, 5-IODOURACIL, CALCIUM ION, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-03 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.377 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
5FC1	Murine SMPDL3A in complex with sulfate 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gorelik, A, Illes, K, Superti-Furga, G, Nagar, B. 登録日 2015-12-14 公開日 2016-01-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.389 Å) 主引用文献 Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. J.Biol.Chem., 291, 2016
7PD9	Crystal structure of CD73 in complex with riboflavin in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-04 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
6ZEI	Structure of PP1-IRSp53 S455E chimera [PP1(7-304) + linker (G/S)x9 + IRSp53(449-465)] bound to Phactr1 (516-580) 分子名称: GLYCEROL, MANGANESE (II) ION, PHOSPHATE ION, ... 著者 Mouilleron, S, Treisman, R, Fedoryshchak, R, Lee, R, Butler, A.M, Prechova, M. 登録日 2020-06-16 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme. Elife, 9, 2020
3H62	Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms complexed with cantharidic acid 分子名称: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 著者 Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. 登録日 2009-04-23 公開日 2009-09-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52, 2009
7P9R	Crystal structure of CD73 in complex with GMP in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, GLYCEROL, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-07-27 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
6GIT	PURPLE ACID PHYTASE FROM WHEAT ISOFORM B2 - PRODUCT COMPLEX 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Faba-Rodriguez, R, Brearley, C.A, Hemmings, A.M. 登録日 2018-05-15 公開日 2019-11-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.418 Å) 主引用文献 Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants. Plant Commun., 3, 2022
7PBA	Crystal structure of CD73 in complex with IMP in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, GLYCEROL, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-01 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
3RL3	Rat metallophosphodiesterase MPPED2 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Podobnik, M, Dermol, U. 登録日 2011-04-19 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. J.Mol.Biol., 412, 2011

 

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