8QJZ
Crystal structure of E. coli LpxH in complex with lipid X
Summary for 8QJZ
Entry DOI | 10.2210/pdb8qjz/pdb |
Descriptor | UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, ... (4 entities in total) |
Functional Keywords | lipid a biosynthesis pathway endotoxin udp-diacyl-glucosamine lipid x gram-negative bacteria lipopolysaccharides hydrolase, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 28684.94 |
Authors | Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2023-09-14, release date: 2024-04-17) |
Primary citation | Huseby, D.L.,Cao, S.,Zamaratski, E.,Sooriyaarachchi, S.,Ahmad, S.,Bergfors, T.,Krasnova, L.,Pelss, J.,Ikaunieks, M.,Loza, E.,Katkevics, M.,Bobileva, O.,Cirule, H.,Gukalova, B.,Grinberga, S.,Backlund, M.,Simoff, I.,Leber, A.T.,Berruga-Fernandez, T.,Antonov, D.,Konda, V.R.,Lindstrom, S.,Olanders, G.,Brandt, P.,Baranczewski, P.,Vingsbo Lundberg, C.,Liepinsh, E.,Suna, E.,Jones, T.A.,Mowbray, S.L.,Hughes, D.,Karlen, A. Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121:e2317274121-e2317274121, 2024 Cited by PubMed: 38579010DOI: 10.1073/pnas.2317274121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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