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4GB0
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BU of 4gb0 by Molmil
Crystal Structure of the RING domain of RNF168
分子名称: E3 ubiquitin-protein ligase RNF168, MALONATE ION, ZINC ION
著者Zhang, X.Q, Wang, C.L, Zang, J.Y.
登録日2012-07-26
公開日2013-07-10
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for role of ring finger protein RNF168 RING domain
Cell Cycle, 12, 2013
2K4D
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BU of 2k4d by Molmil
E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity
分子名称: E3 ubiquitin-protein ligase CBL, ZINC ION
著者Huang, A, De Jong, R.N, Wienk, H, Winkler, S.G, Timmers, H.T.M, Boelens, R.
登録日2008-06-06
公開日2009-01-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity
J.Mol.Biol., 385, 2009
2ECW
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BU of 2ecw by Molmil
Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30
分子名称: Tripartite motif-containing protein 30, ZINC ION
著者Abe, H, Miyamoto, K, Tochio, N, Yoneyama, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-02-14
公開日2008-02-26
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30
To be Published
5YUF
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BU of 5yuf by Molmil
Crystal Structure of PML RING tetramer
分子名称: Protein PML, ZINC ION
著者Wang, P, Benhend, S, Wu, H, Breitenbach, V, Zhen, T, Jollivet, F, Peres, L, Li, Y, Chen, S, Chen, Z, de THE, H, Meng, G.
登録日2017-11-22
公開日2018-04-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献RING tetramerization is required for nuclear body biogenesis and PML sumoylation.
Nat Commun, 9, 2018
6IR0
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BU of 6ir0 by Molmil
Zinc finger domain of the human DTX protein
分子名称: Probable E3 ubiquitin-protein ligase DTX2, ZINC ION
著者Miyamoto, K.
登録日2018-11-09
公開日2019-11-13
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Zinc finger domain of the human DTX protein adopts a unique RING fold.
Protein Sci., 28, 2019
4R7E
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BU of 4r7e by Molmil
Structure of Bre1 RING domain
分子名称: E3 ubiquitin-protein ligase BRE1, ZINC ION
著者Kumar, P, Wolberger, C.
登録日2014-08-27
公開日2015-05-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.251 Å)
主引用文献Structure of the yeast Bre1 RING domain.
Proteins, 83, 2015
3L11
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BU of 3l11 by Molmil
Crystal Structure of the Ring Domain of RNF168
分子名称: E3 ubiquitin-protein ligase RNF168, MALONATE ION, ZINC ION
著者Neculai, D, Yermekbayeva, L, Crombet, L, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2009-12-10
公開日2010-01-19
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
J.Biol.Chem., 287, 2012
2LDR
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BU of 2ldr by Molmil
Solution structure of Helix-RING domain of Cbl-b in the Tyr363 phosphorylated form
分子名称: E3 ubiquitin-protein ligase CBL-B, ZINC ION
著者Kumeta, H, Kobashigawa, Y, Inagaki, F.
登録日2011-06-01
公開日2011-12-14
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
Proc.Natl.Acad.Sci.USA, 108, 2011
1CHC
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BU of 1chc by Molmil
STRUCTURE OF THE C3HC4 DOMAIN BY 1H-NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; A NEW STRUCTURAL CLASS OF ZINC-FINGER
分子名称: EQUINE HERPES VIRUS-1 RING DOMAIN, ZINC ION
著者Barlow, P.N, Everett, R.D, Luisi, B.
登録日1994-02-02
公開日1994-04-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-finger.
J.Mol.Biol., 237, 1994
2MWX
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BU of 2mwx by Molmil
The RING Domain of human Promyelocytic Leukemia Protein (PML)
分子名称: Protein PML, ZINC ION
著者Huang, S.Y, Chang, C.F, Fan, P.J, Guntert, P, Shih, H.M, Huang, T.H.
登録日2014-12-02
公開日2015-02-11
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The RING domain of human promyelocytic leukemia protein (PML).
J.Biomol.Nmr, 61, 2015
1BOR
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BU of 1bor by Molmil
TRANSCRIPTION FACTOR PML, A PROTO-ONCOPROTEIN, NMR, 1 REPRESENTATIVE STRUCTURE AT PH 7.5, 30 C, IN THE PRESENCE OF ZINC
分子名称: TRANSCRIPTION FACTOR PML, ZINC ION
著者Borden, K.L.B, Freemont, P.S.
登録日1995-09-27
公開日1997-04-01
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.
EMBO J., 14, 1995
5H7R
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BU of 5h7r by Molmil
Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain
分子名称: E3 ubiquitin-protein ligase LNX, ZINC ION
著者Nayak, D, Sivaraman, J.
登録日2016-11-21
公開日2017-11-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1.
J. Mol. Biol., 430, 2018
5TRB
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BU of 5trb by Molmil
Crystal structure of the RNF20 RING domain
分子名称: E3 ubiquitin-protein ligase BRE1A, ZINC ION
著者Foglizzo, M, Middleton, A.J, Day, C.L.
登録日2016-10-25
公開日2016-11-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B.
J.Mol.Biol., 428, 2016
6DBO
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BU of 6dbo by Molmil
Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs
分子名称: CALCIUM ION, Forward strand of substrate RSS DNA, Recombination activating gene 1 - MBP chimera, ...
著者Wu, H, Liao, M, Ru, H, Mi, W.
登録日2018-05-03
公開日2018-08-01
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献DNA melting initiates the RAG catalytic pathway.
Nat. Struct. Mol. Biol., 25, 2018
1FBV
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BU of 1fbv by Molmil
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
分子名称: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ...
著者Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P.
登録日2000-07-17
公開日2000-08-30
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
7LYB
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BU of 7lyb by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c
分子名称: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
登録日2021-03-06
公開日2021-07-28
最終更新日2021-09-01
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
6V0V
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BU of 6v0v by Molmil
Cryo-EM structure of mouse WT RAG1/2 NFC complex (DNA0)
分子名称: CALCIUM ION, DNA (30-MER), V(D)J recombination-activating protein 1, ...
著者Chen, X, Yang, W, Gellert, M.
登録日2019-11-19
公開日2020-01-29
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.61 Å)
主引用文献Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
1RMD
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BU of 1rmd by Molmil
RAG1 DIMERIZATION DOMAIN
分子名称: RAG1, ZINC ION
著者Bellon, S.F, Rodgers, K.K, Schatz, D.G, Coleman, J.E, Steitz, T.A.
登録日1997-01-10
公開日1997-07-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.
Nat.Struct.Biol., 4, 1997
6FGA
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BU of 6fga by Molmil
Crystal structure of TRIM21 E3 ligase, RING domain in complex with its cognate E2 conjugating enzyme UBE2E1
分子名称: E3 ubiquitin-protein ligase TRIM21, GLYCEROL, Ubiquitin-conjugating enzyme E2 E1, ...
著者Anandapadamanaban, M, Moche, M, Sunnerhagen, M.
登録日2018-01-10
公開日2019-06-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
J.Biol.Chem., 294, 2019
7JZV
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BU of 7jzv by Molmil
Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome
分子名称: BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ...
著者Witus, S.R, Burrell, A.L, Hansen, J.M, Farrell, D.P, Dimaio, F, Kollman, J.M, Klevit, R.E.
登録日2020-09-02
公開日2021-02-17
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1.
Nat.Struct.Mol.Biol., 28, 2021
1JM7
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BU of 1jm7 by Molmil
Solution structure of the BRCA1/BARD1 RING-domain heterodimer
分子名称: BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1, BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, ZINC ION
著者Brzovic, P.S, Rajagopal, P, Hoyt, D.W, King, M.-C, Klevit, R.E.
登録日2001-07-17
公開日2001-10-03
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
Nat.Struct.Biol., 8, 2001
8IEJ
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BU of 8iej by Molmil
RNF20-RNF40/hRad6A-Ub/nucleosome complex
分子名称: DNA (147-MER), E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, ...
著者Ai, H, Deng, Z, Sun, M, Du, Y, Pan, M, Liu, L.
登録日2023-02-15
公開日2023-09-06
最終更新日2023-09-20
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.
Mol.Cell, 83, 2023
3KNV
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BU of 3knv by Molmil
Crystal structure of the RING and first zinc finger domains of TRAF2
分子名称: TNF receptor-associated factor 2, ZINC ION
著者Yin, Q, Wu, H.
登録日2009-11-12
公開日2009-11-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
Biochemistry, 48, 2009
7OIM
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BU of 7oim by Molmil
Mouse RNF213, with mixed nucleotides bound
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, E3 ubiquitin-protein ligase RNF213, ...
著者Grabarczyk, D, Ahel, J, Clausen, T.
登録日2021-05-11
公開日2022-06-01
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
To Be Published
7OIK
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BU of 7oik by Molmil
Mouse RNF213:UBE2L3 transthiolation intermediate, chemically stabilized
分子名称: ADENOSINE-5'-TRIPHOSPHATE, E3 ubiquitin-protein ligase RNF213, MAGNESIUM ION, ...
著者Grabarczyk, D, Ahel, J, Clausen, T.
登録日2021-05-11
公開日2022-06-01
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
To Be Published

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