PDB: 347 件ウェブページステータス検索Chemie searchBIRD

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4JT5	mTORdeltaN-mLST8-pp242 complex 分子名称: 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSV	mTOR kinase structure, mechanism and regulation. 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSP	structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSX	structure of mTORDeltaN-mLST8-Torin2 complex 分子名称: 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSN	structure of mTORdeltaN-mLST8 complex 分子名称: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JT6	structure of mTORDeltaN-mLST8-PI-103 complex 分子名称: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, mLST8, mTOR 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
6BCX	mTORC1 structure refined to 3.0 angstroms 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... 著者 Pavletich, N.P, Yang, H. 登録日 2017-10-20 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5H64	Cryo-EM structure of mTORC1 分子名称: Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Yang, H, Wang, J, Liu, M, Chen, X, Huang, M, Tan, D, Dong, M, Wong, C.C.L, Wang, J, Xu, Y, Wang, H. 登録日 2016-11-10 公開日 2017-01-25 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1 Protein Cell, 7, 2016
6SB0	cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... 著者 Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. 登録日 2019-07-18 公開日 2019-10-16 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (5.5 Å) 主引用文献 Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
6SB2	cryo-EM structure of mTORC1 bound to active RagA/C GTPases 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... 著者 Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. 登録日 2019-07-18 公開日 2019-10-16 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (6.2 Å) 主引用文献 Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
6ZWO	cryo-EM structure of human mTOR complex 2, focused on one half 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
6ZWM	cryo-EM structure of human mTOR complex 2, overall refinement 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
5ZCS	4.9 Angstrom Cryo-EM structure of human mTOR complex 2 分子名称: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... 著者 Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. 登録日 2018-02-20 公開日 2018-03-21 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
7OWG	human DEPTOR in a complex with mutant human mTORC1 A1459P 分子名称: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... 著者 Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
7PE9	cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEB	cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEC	cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.24 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE8	cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEA	cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.07 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE7	cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-15 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
6BCU	Cryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstrom 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, GTP-binding protein Rheb, ... 著者 Pavletich, N.P, Yang, H. 登録日 2017-10-20 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5FLC	Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction 分子名称: FKBP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, REGULATORY-ASSOCIATED PROTEIN OF MTOR, ... 著者 Aylett, C.H.S, Sauer, E, Imseng, S, Boehringer, D, Hall, M.N, Ban, N, Maier, T. 登録日 2015-10-23 公開日 2015-12-30 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 Architecture of Human Mtor Complex 1 Science, 351, 2016
8ERA	RMC-5552 in complex with mTORC1 and FKBP12 分子名称: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... 著者 Tomlinson, A.C.A, Yano, J.K. 登録日 2022-10-11 公開日 2022-12-28 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023
5WBU	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBH	Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1 分子名称: Ribosomal protein S6 kinase beta-1, Serine/threonine-protein kinase mTOR 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017

 

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