PDB: 12045 件ウェブページステータス検索Chemie searchBIRD

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5NP0	Closed dimer of human ATM (Ataxia telangiectasia mutated) 分子名称: Serine-protein kinase ATM 著者 Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. 登録日 2017-04-13 公開日 2017-05-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
5NP1	Open protomer of human ATM (Ataxia telangiectasia mutated) 分子名称: Serine-protein kinase ATM 著者 Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. 登録日 2017-04-13 公開日 2017-05-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
7NI5	Human ATM kinase with bound inhibitor KU-55933 分子名称: 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, Serine-protein kinase ATM, ZINC ION 著者 Bartho, J.D, Stakyte, K, Rotheneder, M, Lammens, K, Hopfner, K.P. 登録日 2021-02-11 公開日 2021-09-01 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.78 Å) 主引用文献 Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28, 2021
7NI6	Human ATM kinase with bound ATPyS 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ... 著者 Stakyte, K, Rotheneder, M, Lammens, K, Bartho, J.D. 登録日 2021-02-11 公開日 2021-09-01 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28, 2021
7NI4	Human ATM kinase domain with bound M4076 inhibitor 分子名称: 8-(1,3-dimethylpyrazol-4-yl)-1-(3-fluoranyl-5-methoxy-pyridin-4-yl)-7-methoxy-3-methyl-imidazo[4,5-c]quinolin-2-one, Serine-protein kinase ATM, ZINC ION 著者 Stakyte, K, Rotheneder, M. 登録日 2021-02-11 公開日 2021-09-01 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28, 2021
7SIC	Human ATM Dimer 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM 著者 Warren, C, Pavletich, N.P. 登録日 2021-10-13 公開日 2022-02-02 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.51 Å) 主引用文献 Structure of the human ATM kinase and mechanism of Nbs1 binding. Elife, 11, 2022
7SID	Human ATM Dimer Bound to Nbs1 分子名称: MAGNESIUM ION, Nibrin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Warren, C, Pavletich, N.P. 登録日 2021-10-13 公開日 2022-02-02 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.53 Å) 主引用文献 Structure of the human ATM kinase and mechanism of Nbs1 binding. Elife, 11, 2022
7PSL	S. cerevisiae Atm1 in MSP1D1 nanodiscs in nucleotide-free state 分子名称: (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE, Iron-sulfur clusters transporter ATM1, mitochondrial, ... 著者 Ellinghaus, T.L, Kuehlbrandt, W. 登録日 2021-09-23 公開日 2021-12-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv, 7, 2021
7PSM	S. cerevisiae Atm1 in MSP1D1 nanodiscs with bound AMP-PNP and Mg2+ 分子名称: (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE, Iron-sulfur clusters transporter ATM1, mitochondrial, ... 著者 Ellinghaus, T.L, Kuehlbrandt, W. 登録日 2021-09-23 公開日 2021-12-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv, 7, 2021
7PSN	S. cerevisiae Atm1 in MSP1E3D1 nanodiscs with bound AMP-PNP and Mg2+ 分子名称: (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE, Iron-sulfur clusters transporter ATM1, mitochondrial, ... 著者 Ellinghaus, T.L, Kuehlbrandt, W. 登録日 2021-09-23 公開日 2021-12-29 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv, 7, 2021
4MYC	Structure of the mitochondrial ABC transporter, Atm1 分子名称: Iron-sulfur clusters transporter ATM1, mitochondrial 著者 Srinivasan, V. 登録日 2013-09-27 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science, 343, 2014
4MYH	Structure of the Glutathione bound mitochondrial ABC transporter, Atm1 分子名称: GLUTATHIONE, Iron-sulfur clusters transporter ATM1, mitochondrial 著者 Srinivasan, V. 登録日 2013-09-27 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.38 Å) 主引用文献 Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science, 343, 2014
2F7C	CatM effector binding domain with its effector cis,cis-muconate 分子名称: (2Z,4Z)-HEXA-2,4-DIENEDIOIC ACID, HTH-type transcriptional regulator catM, SULFATE ION 著者 Clark, T, Haddad, S, Ezezika, O, Neidle, E, Momany, C. 登録日 2005-11-30 公開日 2006-10-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.162 Å) 主引用文献 Distinct Effector-binding Sites Enable Synergistic Transcriptional Activation by BenM, a LysR-type Regulator. J.Mol.Biol., 367, 2007
2F7B	CatM effector binding domain 分子名称: CHLORIDE ION, HTH-type transcriptional regulator catM, SULFATE ION 著者 Clark, T, Haddad, S, Ezezika, O, Neidle, E, Momany, C. 登録日 2005-11-30 公開日 2006-10-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Distinct Effector-binding Sites Enable Synergistic Transcriptional Activation by BenM, a LysR-type Regulator. J.Mol.Biol., 367, 2007
6K9L	4.27 Angstrom resolution cryo-EM structure of human dimeric ATM kinase 分子名称: Serine-protein kinase ATM 著者 Xiao, J, Liu, M, Qi, Y, Chaban, Y, Gao, C, Tian, Y, Yu, Z, Li, J, Zhang, P, Xu, Y. 登録日 2019-06-16 公開日 2019-12-25 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.27 Å) 主引用文献 Structural insights into the activation of ATM kinase. Cell Res., 29, 2019
6S8F	Structure of nucleotide-bound Tel1/ATM 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1 著者 Yates, L.A, Williams, R.M, Ayala, R, Zhang, X. 登録日 2019-07-09 公開日 2019-10-30 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM Structure of Nucleotide-Bound Tel1ATMUnravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations. Structure, 28, 2020
6HKA	The solution structure of the micelle-associated FATC domain of the human protein kinase ataxia telangiectasia mutated (ATM) 分子名称: Immunoglobulin G-binding protein G,Serine-protein kinase ATM 著者 Abd Rahim, M.S, Dames, S.A. 登録日 2018-09-06 公開日 2019-03-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NMR- and MD simulation-based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated. J.Biol.Chem., 294, 2019
6K9K	Monomeric human ATM (Ataxia telangiectasia mutated) kinase 分子名称: Serine-protein kinase ATM 著者 Xiao, J, Liu, M, Qi, Y, Yuriy, C, Zhang, P, Xu, Y. 登録日 2019-06-16 公開日 2019-12-25 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (7.82 Å) 主引用文献 Structural insights into the activation of ATM kinase. Cell Res., 29, 2019
2H98	Crystal structure of the effector binding domain of a CatM variant, CatM(V158M) 分子名称: CHLORIDE ION, HTH-type transcriptional regulator catM 著者 Ezezika, O.C, Neidle, E.L, Momany, C. 登録日 2006-06-09 公開日 2007-06-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the altered regulatory roles of three LysR-type transcritional variants of CatM and BenM: CatM(V158M), CatM(R156H) and BenM(R156H/T157S) To be Published
8OXQ	ATM(Q2971A) dimeric C-terminal region in complex with Mg AMP-PNP 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ... 著者 Howes, A.C, Perisic, O, Williams, R.L. 登録日 2023-05-02 公開日 2023-09-27 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
8OXO	ATM(Q2971A) dimeric C-terminal region activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide 分子名称: Cellular tumor antigen p53, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Howes, A.C, Perisic, O, Williams, R.L. 登録日 2023-05-02 公開日 2023-09-27 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
8OXP	ATM(Q2971A) in complex with Mg AMP-PNP 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ... 著者 Howes, A.C, Perisic, O, Williams, R.L. 登録日 2023-05-02 公開日 2023-09-27 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
8OXM	ATM(Q2971A) activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide 分子名称: Cellular tumor antigen p53, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Howes, A.C, Perisic, O, Williams, R.L. 登録日 2023-05-02 公開日 2023-09-27 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
6JXA	Tel1 kinase compact monomer 分子名称: Serine/threonine-protein kinase TEL1 著者 Xin, J. 登録日 2019-04-23 公開日 2019-07-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Res., 29, 2019
6JXC	Tel1 kinase butterfly symmetric dimer 分子名称: Serine/threonine-protein kinase TEL1 著者 Xin, J. 登録日 2019-04-23 公開日 2019-07-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Res., 29, 2019

 

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