6S8F

Structure of nucleotide-bound Tel1/ATM

Summary for 6S8F

EMDB information10120
DescriptorSerine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION (3 entities in total)
Functional Keywordskinase, dna damage response, cryoem, phosphatidylinositol-3-kinase-like kinase, hydrolase
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Total number of polymer chains2
Total molecular weight586219.81
Authors
Yates, L.A.,Williams, R.M.,Ayala, R.,Zhang, X. (deposition date: 2019-07-09, release date: 2019-10-30, Last modification date: 2020-01-15)
Primary citation
Yates, L.A.,Williams, R.M.,Hailemariam, S.,Ayala, R.,Burgers, P.,Zhang, X.
Cryo-EM Structure of Nucleotide-Bound Tel1ATMUnravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations.
Structure, 28:96-104.e3, 2020
PubMed: 31740029 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2019.10.012
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliers7 0.1% 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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