PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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3M5T	Fragment tethered to Carbonic Anhydrase II H64C mutant 分子名称: 3,3-diphenyl-N-(2-sulfanylethyl)propanamide, CARBONATE ION, Carbonic anhydrase 2, ... 著者 Schulze Wischeler, J, Heine, A, Klebe, G. 登録日 2010-03-13 公開日 2011-05-25 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fragment screening on Carbonic Anhydrase II via Tethering approach To be Published
4FYM	Crystal structure of Plasmodium falciparum orotate phosphoribosyltransferase 分子名称: Orotate phosphoribosyltransferase, SULFATE ION 著者 Rathod, P.K, Kumar, S. 登録日 2012-07-05 公開日 2013-08-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions. Acta Crystallogr F Struct Biol Commun, 71, 2015
2FR1	The first ketoreductase of the erythromycin synthase (crystal form 2) 分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, erythromycin synthase, EryAI 著者 Keatinge-Clay, A.T, Stroud, R.M. 登録日 2006-01-18 公開日 2006-04-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases Structure, 14, 2006
4G10	LigG from Sphingobium sp. SYK-6 is related to the glutathione transferase omega class 分子名称: ACETATE ION, GLUTATHIONE, Glutathione S-transferase homolog, ... 著者 Meux, E, Prosper, P, Masai, E, Mulliert Carlin, G, Dumarcay, S, Morel, M, Didierjean, C, Gelhaye, E, Favier, F. 登録日 2012-07-10 公開日 2012-10-03 最終更新日 2025-03-26 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Sphingobium sp. SYK-6 LigG involved in lignin degradation is structurally and biochemically related to the glutathione transferase omega class. Febs Lett., 586, 2012
1S8O	Human soluble Epoxide Hydrolase 分子名称: HEXAETHYLENE GLYCOL, epoxide hydrolase 2, cytoplasmic 著者 Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W. 登録日 2004-02-03 公開日 2004-04-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis Biochemistry, 43, 2004
6R99	Crystal Structure of Human CLN protein 5 (Ceroid Lipofuscinosis Neuronal Protein 5) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ceroid-lipofuscinosis neuronal protein 5, ... 著者 Luebben, A.V, Sheldrick, G.M. 登録日 2019-04-03 公開日 2020-04-22 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Cln5 represents a new type of cysteine-based S -depalmitoylase linked to neurodegeneration. Sci Adv, 8, 2022
2FVU	Structure of the yeast Sir3 BAH domain 分子名称: Regulatory protein SIR3 著者 Xu, R.M. 登録日 2006-01-31 公開日 2006-09-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain. Mol.Cell.Biol., 26, 2006
3P6E	Human adipocyte lipid-binding protein FABP4 in complex with 3-(4-methoxyphenyl) propionic acid 分子名称: 3-(4-methoxyphenyl)propanoic acid, Fatty acid-binding protein, adipocyte 著者 Gonzalez, J.M, Pozharski, E. 登録日 2010-10-11 公開日 2011-04-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.08 Å) 主引用文献 Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4). Acta Crystallogr F Struct Biol Commun, 71, 2015
6HHH	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 31 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[4-[4-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperazin-1-yl]phenyl]propanamide 著者 Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. 登録日 2018-08-28 公開日 2019-02-20 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
3P71	Crystal structure of the complex of LCMT-1 and PP2A 分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, DI(HYDROXYETHYL)ETHER, Leucine carboxyl methyltransferase 1, ... 著者 Xing, Y, Stanevich, V, Satyshur, K.A, Jiang, L. 登録日 2010-10-11 公開日 2011-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1. Mol.Cell, 41, 2011
1JO6	Solution structure of the cytoplasmic N-terminus of the BK beta-subunit KCNMB2 分子名称: potassium large conductance calcium-activated channel, subfamily M, beta member 2 著者 Bentrop, D, Beyermann, M, Wissmann, R, Fakler, B. 登録日 2001-07-27 公開日 2001-11-16 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR structure of the "ball-and-chain" domain of KCNMB2, the beta 2-subunit of large conductance Ca2+- and voltage-activated potassium channels. J.Biol.Chem., 276, 2001
8FPT	STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE 分子名称: Alpha-synuclein 著者 Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D. 登録日 2023-01-05 公開日 2023-02-22 最終更新日 2024-12-11 実験手法 SOLID-STATE NMR 主引用文献 Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. Nat Commun, 15, 2024
4FJC	Structure of the SAGA Ubp8/Sgf11(1-72, Delta-ZnF)/Sus1/Sgf73 DUB module 分子名称: GLYCEROL, Protein SUS1, SAGA-associated factor 11, ... 著者 Samara, N.L, Ringel, A.E, Wolberger, C. 登録日 2012-06-11 公開日 2012-07-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.826 Å) 主引用文献 A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity. Structure, 20, 2012
1JDF	Glucarate Dehydratase from E.coli N341D mutant 分子名称: 2,3-DIHYDROXY-5-OXO-HEXANEDIOATE, Glucarate Dehydratase, ISOPROPYL ALCOHOL, ... 著者 Gulick, A.M, Hubbard, B.K, Gerlt, J.A, Rayment, I. 登録日 2001-06-13 公開日 2001-09-05 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli. Biochemistry, 40, 2001
4BD3	Phf19 links methylated lysine 36 of histone H3 to regulation of Polycomb activity 分子名称: HISTONE H3, PHD FINGER PROTEIN 19 著者 Lapinaite, A, Simon, B, Carlomagno, T. 登録日 2012-10-04 公開日 2012-10-31 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Phf19 Links Methylated Lys36 of Histone H3 to Regulation of Polycomb Activity Nat.Struct.Mol.Biol., 19, 2012
2FNN	Activation of human carbonic anhydrase II by exogenous proton donors 分子名称: 4-METHYLIMIDAZOLE, Carbonic Anhydrase 2, ZINC ION 著者 Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. 登録日 2006-01-11 公開日 2006-11-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
2FNK	Activation of Human Carbonic Anhydrase II by exogenous proton donors 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. 登録日 2006-01-11 公開日 2006-11-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
2C1B	Structure of cAMP-dependent protein kinase complexed with (4R,2S)-5'-(4-(4-Chlorobenzyloxy)pyrrolidin-2-ylmethanesulfonyl)isoquinoline 分子名称: (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE, CAMP-DEPENDENT PROTEIN KINASE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR 著者 Collins, I, Caldwell, J, Fonseca, T, Donald, A, Bavetsias, V, Hunter, L.J, Garrett, M.D, Rowlands, M.G, Aherne, G.W, Davies, T.G, Berdini, V, Woodhead, S.J, Seavers, L.C.A, Wyatt, P.G, Workman, P, McDonald, E. 登録日 2005-09-12 公開日 2005-11-02 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B. Bioorg. Med. Chem., 14, 2006
3MFW	Crystal structure of human arginase I in complex with L-2-aminohistidine and sulphate 分子名称: 2-amino-L-histidine, Arginase-1, MANGANESE (II) ION, ... 著者 Di Costanzo, L, Christianson, D.W. 登録日 2010-04-04 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J.Med.Chem., 53, 2010
1BFR	IRON STORAGE AND ELECTRON TRANSPORT 分子名称: BACTERIOFERRITIN, MANGANESE (II) ION, PROTOPORPHYRIN IX CONTAINING FE 著者 Dautant, A, Yariv, J, Meyer, J.B, Precigoux, G, Sweet, R.M, Frolow, F, Kalb(Gilboa), A.J. 登録日 1994-12-16 公開日 1996-06-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Structure of a monoclinic crystal from of cyctochrome b1 (Bacterioferritin) from E. coli. Acta Crystallogr.,Sect.D, 54, 1998
4B5V	Crystal structures of divalent metal dependent pyruvate aldolase, HpaI, in complex with 4-hydroxyl-2-ketoheptane-1,7-dioate 分子名称: (4R)-4-oxidanyl-2-oxidanylidene-heptanedioic acid, 4-HYDROXY-2-OXO-HEPTANE-1,7-DIOATE ALDOLASE, GLYCEROL, ... 著者 Coincon, M, Wang, W, Seah, S.Y.K, Sygusch, J. 登録日 2012-08-07 公開日 2012-08-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.041 Å) 主引用文献 Crystal Structure of Reaction Intermediates in Pyruvate Class II Aldolase: Substrate Cleavage, Enolate Stabilization and Substrate Specificity J.Biol.Chem., 287, 2012
3TFL	LytR-Cps2a-Psr family protein with bound octaprenyl pyrophosphate lipid 分子名称: (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl trihydrogen diphosphate, 1,2-ETHANEDIOL, CPS2A, ... 著者 Kawai, Y, Marles-Wright, J, Cleverley, R.M, Emmins, R, Ishikawa, S, Kuwano, M, Heinz, N, Khai Bui, N, Hoyland, C.N, Ogasawara, N, Lewis, R.J, Vollmer, W, Daniel, R.A, Errington, J. 登録日 2011-08-16 公開日 2011-10-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 A widespread family of bacterial cell wall assembly proteins. Embo J., 30, 2011
4JCQ	ClpP1 from Listeria monocytogenes 分子名称: ATP-dependent Clp protease proteolytic subunit 著者 Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S. 登録日 2013-02-22 公開日 2013-06-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc.Natl.Acad.Sci.USA, 110, 2013
2FOS	Human Carbonic Anhydrase II complexed with two-prong inhibitors 分子名称: COPPER (II) ION, Carbonic Anhydrase II, ZINC ION, ... 著者 Jude, K.M, Christianson, D.W. 登録日 2006-01-13 公開日 2006-04-04 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
1SO3	Crystal structure of H136A mutant of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate 分子名称: 3-keto-L-gulonate 6-phosphate decarboxylase, L-THREONOHYDROXAMATE 4-PHOSPHATE, MAGNESIUM ION 著者 Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. 登録日 2004-03-12 公開日 2004-06-08 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Evolution of Enzymatic Activities in the Orotidine 5'-Monophosphate Decarboxylase Suprafamily: Crystallographic Evidence for a Proton Relay System in the Active Site of 3-Keto-l-gulonate 6-Phosphate Decarboxylase(,) Biochemistry, 43, 2004

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