3MFW
Crystal structure of human arginase I in complex with L-2-aminohistidine and sulphate
Summary for 3MFW
| Entry DOI | 10.2210/pdb3mfw/pdb |
| Related | 3MFV |
| Descriptor | Arginase-1, SULFATE ION, 2-amino-L-histidine, ... (5 entities in total) |
| Functional Keywords | manganese coordination, 2-aminoimidazole derivative, structure based design, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P05089 |
| Total number of polymer chains | 2 |
| Total formula weight | 70311.97 |
| Authors | Di Costanzo, L.,Christianson, D.W. (deposition date: 2010-04-04, release date: 2010-05-05, Last modification date: 2023-09-06) |
| Primary citation | Ilies, M.,Di Costanzo, L.,North, M.L.,Scott, J.A.,Christianson, D.W. 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J.Med.Chem., 53:4266-4276, 2010 Cited by PubMed: 20441173DOI: 10.1021/jm100306a PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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